SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 12 GLU A 355
GLY A 353
ASN A 348
ASP A 356
ALA A 306
 None
None
SO4  A 405 (-4.5A)
None
None
 1.26A 2br4B-5wxiA:
4.1		 2br4B-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5wxi EARP
(Neisseria
meningitidis) 		4 / 5 LEU A  27
ILE A 152
LEU A 151
SER A 366
 None
 0.87A 2byoA-5wxiA:
undetectable		 2byoA-5wxiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 11 GLN A 231
ALA A 229
ALA A 211
GLY A 212
THR A 213
 None
None
TRH  A 401 (-3.6A)
SO4  A 408 (-3.4A)
SO4  A 408 (-3.3A)
 0.97A 2f16H-5wxiA:
undetectable
2f16I-5wxiA:
undetectable		 2f16H-5wxiA:
18.13
2f16I-5wxiA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 11 GLN A 231
ALA A 229
ALA A 211
GLY A 212
THR A 213
 None
None
TRH  A 401 (-3.6A)
SO4  A 408 (-3.4A)
SO4  A 408 (-3.3A)
 0.97A 2f16V-5wxiA:
undetectable
2f16W-5wxiA:
undetectable		 2f16V-5wxiA:
18.13
2f16W-5wxiA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 12 GLY A  22
GLN A 252
VAL A  30
MET A 142
THR A  90
 TRH  A 401 ( 4.0A)
TRH  A 401 ( 4.0A)
None
None
None
 1.33A 2q7lA-5wxiA:
undetectable		 2q7lA-5wxiA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 11 ASP A 256
PHE A 362
GLN A 364
PRO A 368
VAL A  23
 None
 1.41A 2vcdA-5wxiA:
undetectable		 2vcdA-5wxiA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 VAL A  46
TRP A  42
TRP A  71
 SO4  A 406 (-3.9A)
None
None
 1.21A 2xdcA-5wxiA:
undetectable
2xdcB-5wxiA:
undetectable		 2xdcA-5wxiA:
undetectable
2xdcB-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 TRP A  71
VAL A  46
TRP A  42
 None
SO4  A 406 (-3.9A)
None
 1.19A 2xdcA-5wxiA:
undetectable
2xdcB-5wxiA:
undetectable		 2xdcA-5wxiA:
undetectable
2xdcB-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 VAL A  46
TRP A  42
TRP A  71
 SO4  A 406 (-3.9A)
None
None
 1.35A 2xdcC-5wxiA:
undetectable
2xdcD-5wxiA:
undetectable		 2xdcC-5wxiA:
undetectable
2xdcD-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 VAL A  46
TRP A  42
TRP A  71
 SO4  A 406 (-3.9A)
None
None
 1.20A 2y5mA-5wxiA:
undetectable
2y5mB-5wxiA:
undetectable		 2y5mA-5wxiA:
undetectable
2y5mB-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 VAL A  46
TRP A  42
TRP A  71
 SO4  A 406 (-3.9A)
None
None
 1.21A 2y6nA-5wxiA:
undetectable
2y6nB-5wxiA:
undetectable		 2y6nA-5wxiA:
undetectable
2y6nB-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 TRP A  71
VAL A  46
TRP A  42
 None
SO4  A 406 (-3.9A)
None
 1.20A 2y6nA-5wxiA:
undetectable
2y6nB-5wxiA:
undetectable		 2y6nA-5wxiA:
undetectable
2y6nB-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 ASN A 178
ALA A 179
LYS A 177
 None
 0.99A 3runA-5wxiA:
undetectable		 3runA-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 VAL A  46
TRP A  42
TRP A  71
 SO4  A 406 (-3.9A)
None
None
 1.17A 3zq8A-5wxiA:
undetectable
3zq8B-5wxiA:
undetectable		 3zq8A-5wxiA:
undetectable
3zq8B-5wxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 ARG A  29
ARG A  26
TRP A  25
 None
None
BME  A 402 (-4.2A)
 1.47A 4cpzC-5wxiA:
undetectable		 4cpzC-5wxiA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 ARG A  29
ARG A  26
TRP A  25
 None
None
BME  A 402 (-4.2A)
 1.39A 4cpzE-5wxiA:
undetectable		 4cpzE-5wxiA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 5wxi EARP
(Neisseria
meningitidis) 		3 / 3 ARG A  29
ARG A  26
TRP A  25
 None
None
BME  A 402 (-4.2A)
 1.45A 4cpzH-5wxiA:
undetectable		 4cpzH-5wxiA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5wxi EARP
(Neisseria
meningitidis) 		4 / 6 PHE A 273
PHE A 283
ALA A 306
LEU A 361
 None
 0.99A 4ejgD-5wxiA:
undetectable		 4ejgD-5wxiA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5wxi EARP
(Neisseria
meningitidis) 		4 / 4 LEU A 331
LEU A 325
GLN A 341
GLU A 197
 None
 1.26A 4i41A-5wxiA:
undetectable		 4i41A-5wxiA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5wxi EARP
(Neisseria
meningitidis) 		4 / 8 ARG A  33
ARG A  26
GLU A 159
ARG A 275
 None
 1.09A 4kr4C-5wxiA:
undetectable		 4kr4C-5wxiA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 12 LEU A  31
LEU A  35
GLY A  36
VAL A   7
HIS A  67
 None
 1.28A 4olmA-5wxiA:
undetectable		 4olmA-5wxiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 12 SER A 117
ASN A 122
ASP A 297
SER A 145
GLU A 123
 None
 1.10A 5iqeC-5wxiA:
undetectable		 5iqeC-5wxiA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5wxi EARP
(Neisseria
meningitidis) 		5 / 12 LEU A  27
ILE A 152
VAL A 135
GLY A 150
LEU A 371
 None
 1.26A 6a7pA-5wxiA:
undetectable		 6a7pA-5wxiA:
undetectable