SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 230
ASP A 231
ILE B  50
ARG B  46
 None
 1.05A 1mt1A-5wxlA:
undetectable
1mt1F-5wxlA:
undetectable		 1mt1A-5wxlA:
18.12
1mt1F-5wxlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 230
ASP A 231
ILE B  50
ARG B  46
 None
 1.02A 1n13I-5wxlA:
undetectable
1n13L-5wxlA:
undetectable		 1n13I-5wxlA:
18.12
1n13L-5wxlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 135
THR A 134
GLN A 179
ILE A 226
 None
 1.32A 1ss4A-5wxlA:
undetectable		 1ss4A-5wxlA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
REGULATOR OF
RIBOSOME
BIOSYNTHESIS
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 GLY A 167
LYS A 138
LEU B  26
PRO B  95
 None
 1.42A 2dqyA-5wxlA:
undetectable		 2dqyA-5wxlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 230
ASP A 231
ILE B  50
ARG B  46
 None
 1.05A 2qqcG-5wxlA:
undetectable
2qqcJ-5wxlA:
undetectable		 2qqcG-5wxlA:
11.97
2qqcJ-5wxlA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  31
PHE A  78
ILE A  33
PHE A  69
ASP A 112
 None
 1.36A 3ko0C-5wxlA:
undetectable
3ko0D-5wxlA:
undetectable
3ko0E-5wxlA:
undetectable
3ko0F-5wxlA:
undetectable		 3ko0C-5wxlA:
18.85
3ko0D-5wxlA:
18.85
3ko0E-5wxlA:
18.85
3ko0F-5wxlA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 8 LYS B  51
TYR A 204
LEU A 206
SER A 183
 None
 0.99A 3lm8A-5wxlB:
undetectable
3lm8C-5wxlB:
undetectable		 3lm8A-5wxlB:
17.37
3lm8C-5wxlB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 138
LEU A  86
MET A 184
ARG B 101
 None
 1.32A 4bkjA-5wxlA:
undetectable		 4bkjA-5wxlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5wxl REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 138
LEU A  86
MET A 184
ARG B 101
 None
 1.33A 4bkjB-5wxlA:
undetectable		 4bkjB-5wxlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 201
VAL A 118
PHE A 165
PHE A 161
 None
 1.01A 4ejjB-5wxlA:
undetectable		 4ejjB-5wxlA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  35
ILE A 182
PHE A 232
THR A  91
MET A 100
 None
 1.29A 5eslA-5wxlA:
undetectable		 5eslA-5wxlA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 5wxl RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 147
VAL A 153
PHE A 190
ILE A 234
 None
 1.00A 5of1B-5wxlA:
undetectable		 5of1B-5wxlA:
13.65