SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 VAL A 108
ILE A 107
ILE A  37
ILE A  62
LEU A  58
 None
 0.95A 1qhsA-5wxvA:
undetectable		 1qhsA-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 VAL A 108
ILE A 107
ILE A  37
ILE A  62
LEU A  58
 None
 0.95A 1qhyA-5wxvA:
undetectable		 1qhyA-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ILE A 192
LEU A 189
HIS A 153
ALA A 160
LEU A  58
 None
 1.18A 2a58A-5wxvA:
3.4
2a58B-5wxvA:
3.4		 2a58A-5wxvA:
21.38
2a58B-5wxvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ILE A 192
LEU A 189
HIS A 153
ALA A 160
LEU A  58
 None
 1.17A 2a58B-5wxvA:
3.4
2a58C-5wxvA:
3.4		 2a58B-5wxvA:
21.38
2a58C-5wxvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ILE A 192
LEU A 189
HIS A 153
ALA A 160
LEU A  58
 None
 1.18A 2a58D-5wxvA:
3.4
2a58E-5wxvA:
3.4		 2a58D-5wxvA:
21.38
2a58E-5wxvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 5 PRO A  56
ALA A  53
ASP A 104
ASP A  49
 None
 0.91A 2nyuB-5wxvA:
4.7		 2nyuB-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 THR A  79
ILE A 147
LEU A  36
LYS A 129
VAL A 196
 None
 1.16A 3a51C-5wxvA:
undetectable		 3a51C-5wxvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 8 ILE A 154
TRP A  97
PHE A  96
TYR A 125
 None
 1.20A 3ccfB-5wxvA:
3.5		 3ccfB-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 LEU A  59
GLY A 149
VAL A 173
ASP A  39
LEU A 111
 None
 1.10A 3cjtG-5wxvA:
4.2		 3cjtG-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 LEU A  59
ALA A 178
ASP A 179
GLY A 174
VAL A 173
 None
 1.13A 3oxxB-5wxvA:
undetectable		 3oxxB-5wxvA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 ASP A  39
PHE A  44
TRP A  97
LYS A 122
TYR A 125
 None
 0.77A 3r2jB-5wxvA:
19.3		 3r2jB-5wxvA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ASP A  39
PHE A  44
TRP A  97
LYS A 122
TYR A 125
 None
 0.80A 3r2jC-5wxvA:
19.5		 3r2jC-5wxvA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 ASP A  39
PHE A  44
TRP A  97
LYS A 122
TYR A 125
 None
 0.76A 3r2jD-5wxvA:
19.4		 3r2jD-5wxvA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 8 GLN A  81
TRP A  97
GLN A  85
THR A  99
 None
 1.38A 4d1yA-5wxvA:
4.2
4d1yB-5wxvA:
4.0		 4d1yA-5wxvA:
17.00
4d1yB-5wxvA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ALA A 152
GLY A 149
PHE A  44
GLY A 174
GLY A 155
 None
 1.03A 5gwxA-5wxvA:
3.2		 5gwxA-5wxvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		3 / 3 THR A 140
THR A 131
LEU A  36
 None
 0.64A 5m66D-5wxvA:
2.7		 5m66D-5wxvA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5wxv ISOCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 LEU A  59
ALA A 178
ASP A 179
GLY A 174
VAL A 173
 None
 0.99A 6dh6A-5wxvA:
undetectable		 6dh6A-5wxvA:
21.59