SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		3 / 3 PHE A  95
TYR A  81
TYR A 220
 None
 0.93A 1x70B-5wy0A:
undetectable		 1x70B-5wy0A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 8 TYR A 192
PHE A 160
ASN A 134
GLY A 191
 None
 1.03A 1ykiA-5wy0A:
undetectable
1ykiB-5wy0A:
undetectable		 1ykiA-5wy0A:
16.67
1ykiB-5wy0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 8 TYR A 192
PHE A 160
ASN A 134
GLY A 191
 None
 1.04A 1ykiC-5wy0A:
undetectable
1ykiD-5wy0A:
undetectable		 1ykiC-5wy0A:
16.67
1ykiD-5wy0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		3 / 3 ASP A 111
THR A 132
PRO A 133
 None
 0.52A 2q64B-5wy0A:
undetectable		 2q64B-5wy0A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  94
LEU A  24
VAL A  47
TYR A  81
ASP A  89
 None
 1.35A 2vqyA-5wy0A:
2.2		 2vqyA-5wy0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 ILE A 101
LEU A 107
GLU A 105
ASN A  50
THR A 132
 SAM  A 800 (-4.3A)
None
None
None
None
 1.22A 2w3mB-5wy0A:
2.5		 2w3mB-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 6 LEU A 107
ILE A 104
PRO A 116
VAL A 223
 None
 1.03A 2ygoA-5wy0A:
undetectable		 2ygoA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 10 GLY A  27
ASP A  48
ILE A  49
ASN A  50
LEU A 103
 SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-4.4A)
 0.80A 3ay0B-5wy0A:
11.9		 3ay0B-5wy0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 10 GLY A  27
ASP A  48
ILE A  49
ASN A  50
VAL A  85
 SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-3.5A)
 0.65A 3ay0B-5wy0A:
11.9		 3ay0B-5wy0A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 ASP A  23
GLY A  25
ASP A  48
ILE A  49
LEU A 103
 SAM  A 800 ( 4.5A)
SAM  A 800 (-3.6A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
SAM  A 800 (-4.4A)
 0.64A 3cjtC-5wy0A:
12.1		 3cjtC-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 ASP A  23
GLY A  25
ASP A  48
ILE A  49
LEU A 107
 SAM  A 800 ( 4.5A)
SAM  A 800 (-3.6A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
 0.68A 3cjtC-5wy0A:
12.1		 3cjtC-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 ASP A  23
GLY A  25
LEU A  31
ASP A  48
ILE A  49
 SAM  A 800 ( 4.5A)
SAM  A 800 (-3.6A)
None
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
 0.93A 3cjtC-5wy0A:
12.1		 3cjtC-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 ASP A  23
LEU A  24
GLY A  25
ASP A  48
LEU A 103
 SAM  A 800 ( 4.5A)
None
SAM  A 800 (-3.6A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.4A)
 0.86A 3cjtC-5wy0A:
12.1		 3cjtC-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 10 PHE A 177
VAL A 167
PHE A 199
PHE A 120
PHE A 115
 None
 1.47A 3r6wA-5wy0A:
undetectable
3r6wB-5wy0A:
1.8		 3r6wA-5wy0A:
15.24
3r6wB-5wy0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 7 ASP A  48
GLY A  27
ASP A  23
VAL A  85
 SAM  A 800 (-2.8A)
SAM  A 800 (-3.5A)
SAM  A 800 ( 4.5A)
SAM  A 800 (-3.5A)
 0.76A 3t3cA-5wy0A:
undetectable		 3t3cA-5wy0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 9 PHE A 115
PHE A 120
VAL A 167
ILE A 130
THR A 132
 None
 1.37A 3t3rB-5wy0A:
undetectable		 3t3rB-5wy0A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		3 / 3 ASP A 111
THR A 132
PRO A 133
 None
 0.51A 3tkgD-5wy0A:
undetectable		 3tkgD-5wy0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 8 VAL A 167
TRP A 163
PHE A 115
PRO A 125
 None
 0.95A 3v35A-5wy0A:
undetectable		 3v35A-5wy0A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 11 ASP A  23
GLY A  25
GLY A  27
ILE A 101
ASP A  48
 SAM  A 800 ( 4.5A)
SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
SAM  A 800 (-4.3A)
SAM  A 800 (-2.8A)
 0.99A 4dcmA-5wy0A:
9.3		 4dcmA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  25
GLY A  27
ASP A  48
ILE A  49
LEU A 107
 SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
 0.60A 4iv8A-5wy0A:
13.7		 4iv8A-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  25
GLY A  27
ASP A  48
ILE A  49
LEU A 107
 SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
 0.61A 4iv8B-5wy0A:
13.7		 4iv8B-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  25
GLY A  27
SER A  30
ILE A  49
HIS A 106
 SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
None
SAM  A 800 (-4.0A)
SAM  A 800 (-4.1A)
 0.76A 4qdjA-5wy0A:
15.1		 4qdjA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  27
ILE A  49
ASN A  50
SER A  84
ASP A  23
 SAM  A 800 (-3.5A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-3.4A)
SAM  A 800 ( 4.5A)
 1.26A 4rtpA-5wy0A:
10.5		 4rtpA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 11 ASP A  48
ILE A  49
ASN A  50
SER A  84
ASP A  23
 SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-3.4A)
SAM  A 800 ( 4.5A)
 1.03A 4rtrA-5wy0A:
10.6		 4rtrA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		6 / 12 GLY A  27
ASP A  48
ILE A  49
ASN A  50
SER A  84
ASP A  23
 SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-3.4A)
SAM  A 800 ( 4.5A)
 1.23A 4rtsA-5wy0A:
10.2		 4rtsA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 5 ILE A 128
PRO A 125
TYR A 220
VAL A  47
 None
 1.34A 4s0vA-5wy0A:
2.3		 4s0vA-5wy0A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 7 LEU A  92
VAL A 119
ILE A  49
VAL A  85
 None
None
SAM  A 800 (-4.0A)
SAM  A 800 (-3.5A)
 1.15A 5jh7C-5wy0A:
undetectable		 5jh7C-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		5 / 12 GLY A  25
GLY A  27
VAL A  85
LEU A 103
HIS A 106
 SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
SAM  A 800 (-3.5A)
SAM  A 800 (-4.4A)
SAM  A 800 (-4.1A)
 0.76A 5kocB-5wy0A:
11.1		 5kocB-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 5 TYR A  81
VAL A  45
ASP A  23
ALA A  22
 None
None
SAM  A 800 ( 4.5A)
None
 1.13A 5otrA-5wy0A:
undetectable		 5otrA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		12 / 12 GLY A  25
GLY A  27
ASP A  48
ILE A  49
ASN A  50
LYS A  53
SER A  84
VAL A  85
ILE A 101
LEU A 103
HIS A 106
LEU A 107
 SAM  A 800 (-3.6A)
SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-4.8A)
SAM  A 800 (-3.4A)
SAM  A 800 (-3.5A)
SAM  A 800 (-4.3A)
SAM  A 800 (-4.4A)
SAM  A 800 (-4.1A)
None
 0.01A 5wy0A-5wy0A:
39.0		 5wy0A-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens) 		4 / 8 LEU A  44
VAL A  21
THR A  99
VAL A   9
 None
 1.03A 6cp4A-5wy0A:
undetectable		 6cp4A-5wy0A:
undetectable