SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 309
ILE A 331
GLY A 284
ALA A 283
LEU A 279
 None
 0.96A 1eqhA-5wy3A:
undetectable		 1eqhA-5wy3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 309
ILE A 331
GLY A 284
ALA A 283
LEU A 279
 None
 0.94A 1eqhB-5wy3A:
undetectable		 1eqhB-5wy3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ARG A  72
LEU A  61
ASP A  65
LEU A  70
 None
 1.18A 1n13B-5wy3A:
undetectable
1n13C-5wy3A:
undetectable		 1n13B-5wy3A:
15.08
1n13C-5wy3A:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 127
ILE A 263
VAL A 209
ILE A 236
ILE A 266
 None
 1.26A 1r5lA-5wy3A:
undetectable		 1r5lA-5wy3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 MET A 346
ALA A 344
ILE A 343
ASP A 310
 None
 0.97A 1upfA-5wy3A:
undetectable		 1upfA-5wy3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 MET A 346
ALA A 344
ILE A 343
ASP A 310
 None
 0.88A 1upfC-5wy3A:
undetectable		 1upfC-5wy3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 THR A  31
GLU A  41
ALA A  37
TYR A 168
LEU A 249
 None
 1.31A 2azqA-5wy3A:
undetectable		 2azqA-5wy3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 129
ALA A 121
TYR A 168
PHE A 239
LEU A 260
 None
 1.14A 2nyrA-5wy3A:
undetectable		 2nyrA-5wy3A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 236
ALA A 211
VAL A 252
LEU A 240
LEU A 130
 None
 1.34A 2rctA-5wy3A:
undetectable		 2rctA-5wy3A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 1.01A 3n8yA-5wy3A:
undetectable		 3n8yA-5wy3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 THR A 173
THR A 174
SER A 175
PHE A 239
 None
 1.15A 3snfA-5wy3A:
undetectable		 3snfA-5wy3A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 119
HIS A 243
PRO A 176
GLN A 120
LEU A 161
 None
 1.23A 4ac0A-5wy3A:
undetectable		 4ac0A-5wy3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 245
THR A 173
PRO A 124
VAL A 252
ILE A 127
 None
 1.42A 4eb6B-5wy3A:
undetectable
4eb6C-5wy3A:
undetectable		 4eb6B-5wy3A:
21.40
4eb6C-5wy3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASP A  46
VAL A  88
PHE A  64
LEU A  70
 None
 1.04A 4f8hA-5wy3A:
2.6
4f8hB-5wy3A:
2.6		 4f8hA-5wy3A:
23.56
4f8hB-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASP A  46
VAL A  88
PHE A  64
LEU A  70
 None
 1.06A 4f8hB-5wy3A:
2.6
4f8hC-5wy3A:
2.6		 4f8hB-5wy3A:
23.56
4f8hC-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASP A  46
VAL A  88
PHE A  64
LEU A  70
 None
 1.05A 4f8hC-5wy3A:
2.6
4f8hD-5wy3A:
3.8		 4f8hC-5wy3A:
23.56
4f8hD-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASP A  46
VAL A  88
PHE A  64
LEU A  70
 None
 1.05A 4f8hD-5wy3A:
2.6
4f8hE-5wy3A:
2.6		 4f8hD-5wy3A:
23.56
4f8hE-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 VAL A  88
PHE A  64
LEU A  70
ASP A  46
 None
 1.06A 4f8hA-5wy3A:
2.6
4f8hE-5wy3A:
3.8		 4f8hA-5wy3A:
23.56
4f8hE-5wy3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 139
LYS A 136
LYS A 135
 None
 1.33A 4k50A-5wy3A:
2.4		 4k50A-5wy3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 139
LYS A 136
LYS A 135
 None
 1.37A 4k50E-5wy3A:
2.4		 4k50E-5wy3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 139
LYS A 136
LYS A 135
 None
 1.36A 4k50I-5wy3A:
2.4		 4k50I-5wy3A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.92A 4rrwA-5wy3A:
undetectable		 4rrwA-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.92A 4rrwB-5wy3A:
undetectable		 4rrwB-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.91A 4rrwC-5wy3A:
undetectable		 4rrwC-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.94A 4rrxA-5wy3A:
undetectable		 4rrxA-5wy3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.95A 4rrxB-5wy3A:
undetectable		 4rrxB-5wy3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.92A 4rrzA-5wy3A:
undetectable		 4rrzA-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.92A 4rrzB-5wy3A:
undetectable		 4rrzB-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.91A 4rrzC-5wy3A:
undetectable		 4rrzC-5wy3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TYR A  81
PRO A  76
LEU A 109
GLU A 111
 None
 1.42A 4z4cA-5wy3A:
undetectable		 4z4cA-5wy3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ASN A 261
LEU A 257
SER A 259
LEU A 240
 None
 1.32A 5kb5A-5wy3A:
undetectable		 5kb5A-5wy3A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ASN A  45
LEU A  43
SER A  40
PHE A  80
 None
 1.23A 6ekuA-5wy3A:
undetectable		 6ekuA-5wy3A:
19.92