SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ASN A 131
LEU A 135
LEU A 121
LEU A  94
 None
 1.24A 1hk2A-5wy4A:
undetectable		 1hk2A-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ALA A 270
LEU A 201
LEU A 255
LEU A 193
 None
 0.93A 1mt1D-5wy4A:
undetectable
1mt1E-5wy4A:
undetectable		 1mt1D-5wy4A:
18.97
1mt1E-5wy4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 ILE A 214
VAL A 183
LEU A 255
ALA A 258
VAL A 254
 None
 1.09A 1rv7A-5wy4A:
undetectable
1rv7B-5wy4A:
undetectable		 1rv7A-5wy4A:
18.00
1rv7B-5wy4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 THR A 150
GLU A 119
HIS A 128
 None
 0.84A 1xwfA-5wy4A:
undetectable		 1xwfA-5wy4A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 THR A 150
GLU A 119
HIS A 128
 None
 0.84A 1xwfB-5wy4A:
undetectable		 1xwfB-5wy4A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 THR A 150
GLU A 119
HIS A 128
 None
 0.84A 1xwfC-5wy4A:
undetectable		 1xwfC-5wy4A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 THR A 150
GLU A 119
HIS A 128
 None
 0.83A 1xwfD-5wy4A:
undetectable		 1xwfD-5wy4A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 ARG A 319
LEU A 358
ALA A 329
LEU A 296
VAL A 297
 None
 1.04A 2bxgB-5wy4A:
undetectable		 2bxgB-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU A 193
SER A 197
ILE A 251
SER A 256
GLY A 252
 None
 1.46A 3ik6B-5wy4A:
undetectable
3ik6E-5wy4A:
undetectable		 3ik6B-5wy4A:
15.16
3ik6E-5wy4A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU A 193
SER A 197
ILE A 251
SER A 256
GLY A 252
 None
 1.43A 3iluB-5wy4A:
undetectable
3iluE-5wy4A:
undetectable		 3iluB-5wy4A:
15.16
3iluE-5wy4A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 167
PHE A 166
ILE A 182
ALA A 181
 None
 1.07A 3mdrA-5wy4A:
undetectable		 3mdrA-5wy4A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 137
SER A 215
GLY A 212
HIS A 103
SER A 203
 None
 1.04A 3mg02-5wy4A:
undetectable
3mg0V-5wy4A:
undetectable		 3mg02-5wy4A:
18.13
3mg0V-5wy4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 GLY A 252
MET A 259
LEU A 248
ILE A 288
 None
 0.82A 3nbqB-5wy4A:
undetectable		 3nbqB-5wy4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 GLY A 252
MET A 259
LEU A 248
ILE A 288
 None
 0.85A 3nbqC-5wy4A:
undetectable		 3nbqC-5wy4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 354
LEU A 324
ILE A 345
SER A 325
VAL A 335
 None
 1.34A 3w1wA-5wy4A:
undetectable		 3w1wA-5wy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 345
VAL A 351
LEU A 342
ALA A 316
LEU A 312
 None
 1.30A 4m11A-5wy4A:
undetectable		 4m11A-5wy4A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 117
LEU A  73
PHE A 125
ALA A 137
TYR A 199
 None
 1.17A 4pclA-5wy4A:
undetectable		 4pclA-5wy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 HIS A 318
LEU A 289
GLY A 282
LYS A 281
 None
 0.90A 4z69A-5wy4A:
undetectable		 4z69A-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU A 255
ALA A 258
GLU A 257
LEU A 201
GLY A 218
 None
 1.28A 5dxbA-5wy4A:
undetectable		 5dxbA-5wy4A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 SER A 341
PRO A 336
LEU A 309
LEU A 305
 None
 1.14A 5dzkd-5wy4A:
undetectable
5dzkr-5wy4A:
undetectable		 5dzkd-5wy4A:
undetectable
5dzkr-5wy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 LEU A 247
MET A 221
ILE A 288
LEU A 255
 None
 1.41A 5nfpA-5wy4A:
undetectable		 5nfpA-5wy4A:
15.44