SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A  69
LEU A  22
ALA A  85
GLU A 175
 None
 1.23A 1xvaA-5wy5A:
undetectable
1xvaB-5wy5A:
undetectable		 1xvaA-5wy5A:
24.60
1xvaB-5wy5A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5wy5 MELANOMA-ASSOCIATED
ANTIGEN G1
NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		3 / 3 ARG A  17
GLU B 159
GLN A  20
 None
 1.02A 2p16A-5wy5A:
undetectable		 2p16A-5wy5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		4 / 7 GLU A  30
GLU A  29
ARG A  73
LYS A  72
 None
 0.91A 4fgzA-5wy5A:
undetectable		 4fgzA-5wy5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A  21
LEU A  28
ILE A  60
ILE A  57
LEU A  86
 None
 1.30A 4j24C-5wy5A:
undetectable		 4j24C-5wy5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS A 169
GLY A 170
LEU A 174
GLY A  74
THR A  76
 None
 1.06A 5hg0A-5wy5A:
undetectable		 5hg0A-5wy5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS A 169
GLY A 170
LEU A 174
GLY A  74
THR A  76
 None
 1.03A 5hg0B-5wy5A:
undetectable		 5hg0B-5wy5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5wy5 NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG
MELANOMA-ASSOCIATED
ANTIGEN G1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A  16
PHE B 138
GLY B 139
 None
 0.81A 6fgdA-5wy5A:
undetectable		 6fgdA-5wy5A:
20.80