SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wy8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 ARG B 106
ASP B 101
ASN B  63
 None
None
NAG  B 403 (-1.9A)
 0.54A 1nbhA-5wy8B:
undetectable		 1nbhA-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 ARG B 106
ASP B 101
ASN B  63
 None
None
NAG  B 403 (-1.9A)
 0.51A 1nbhD-5wy8B:
undetectable		 1nbhD-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 4 GLY B 311
TYR B 273
GLY B 275
ASP B 276
 None
 1.19A 3kl3A-5wy8B:
undetectable		 3kl3A-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 GLY B  58
TRP B  34
VAL B 129
 None
 0.66A 3n62B-5wy8B:
undetectable		 3n62B-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 GLY B  58
TRP B  34
VAL B 129
 None
 0.64A 3n65B-5wy8B:
undetectable		 3n65B-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 GLY B  58
TRP B  34
VAL B 129
 None
 0.64A 3n66B-5wy8B:
undetectable		 3n66B-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 ILE B 211
THR B 234
GLU B 308
GLU B 312
 None
 1.36A 3ny4A-5wy8B:
undetectable		 3ny4A-5wy8B:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 ILE B 131
GLY B 114
ILE B  51
LEU B 115
 None
 0.87A 5dzki-5wy8B:
undetectable
5dzkj-5wy8B:
undetectable
5dzkx-5wy8B:
undetectable		 5dzki-5wy8B:
undetectable
5dzkj-5wy8B:
undetectable
5dzkx-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 5 ILE B 131
GLY B 114
ILE B  51
LEU B 115
 None
 0.86A 5dzkd-5wy8B:
undetectable
5dzkk-5wy8B:
undetectable
5dzky-5wy8B:
undetectable		 5dzkd-5wy8B:
undetectable
5dzkk-5wy8B:
undetectable
5dzky-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		4 / 4 ILE B 131
GLY B 114
ILE B  51
LEU B 115
 None
 0.83A 5dzkl-5wy8B:
undetectable
5dzkz-5wy8B:
undetectable		 5dzkl-5wy8B:
undetectable
5dzkz-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1
(Homo
sapiens) 		3 / 3 GLY B  58
TRP B  34
VAL B 129
 None
 0.65A 5vuoB-5wy8B:
undetectable		 5vuoB-5wy8B:
undetectable