SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wya'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PHE A 409
LEU A 365
ALA A 343
ARG A 417
ILE A 415
 None
 1.12A 1crbA-5wyaA:
undetectable		 1crbA-5wyaA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.13A 1l5qA-5wyaA:
undetectable		 1l5qA-5wyaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.11A 1l5qB-5wyaA:
undetectable		 1l5qB-5wyaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.13A 1l7xA-5wyaA:
undetectable		 1l7xA-5wyaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 LEU A 215
SER A 137
VAL A 170
ALA A 126
ALA A 212
 None
 0.97A 1n5xA-5wyaA:
undetectable		 1n5xA-5wyaA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 LEU A 215
SER A 137
VAL A 170
ALA A 126
ALA A 212
 None
 0.97A 1n5xB-5wyaA:
undetectable		 1n5xB-5wyaA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 ILE A 135
HIS A 172
VAL A 170
LEU A 167
THR A 160
 None
 0.96A 2aw1A-5wyaA:
undetectable		 2aw1A-5wyaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ARG A 127
THR A 211
ALA A 212
PRO A 207
 None
 1.33A 2ql8A-5wyaA:
undetectable
2ql8B-5wyaA:
undetectable		 2ql8A-5wyaA:
16.93
2ql8B-5wyaA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		3 / 3 GLY A 260
GLY A 340
GLY A 364
 None
 0.42A 3bogD-5wyaA:
undetectable		 3bogD-5wyaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.14A 3dd1A-5wyaA:
undetectable		 3dd1A-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.14A 3dd1B-5wyaA:
undetectable		 3dd1B-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.13A 3ddsA-5wyaA:
undetectable		 3ddsA-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.12A 3ddsB-5wyaA:
undetectable		 3ddsB-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.13A 3ddwA-5wyaA:
undetectable		 3ddwA-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 ASN A 113
HIS A 306
ALA A 311
GLY A 312
 None
 1.13A 3ddwB-5wyaA:
undetectable		 3ddwB-5wyaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 412
GLY A 367
ARG A 361
VAL A 360
ILE A 369
 None
 1.16A 3jb2A-5wyaA:
undetectable		 3jb2A-5wyaA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 10 ILE A 327
PHE A 111
ALA A  98
LEU A  97
ALA A 290
 None
 1.25A 3lw5B-5wyaA:
undetectable		 3lw5B-5wyaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 ILE A 399
GLN A 410
LEU A 407
ILE A 219
GLY A 364
 None
 0.91A 3ozwB-5wyaA:
undetectable		 3ozwB-5wyaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		6 / 12 ALA A  52
LEU A 413
GLY A  60
HIS A  61
ALA A 319
ASN A  58
 None
 1.14A 3tm4A-5wyaA:
2.5		 3tm4A-5wyaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 ALA A  52
LEU A 413
GLY A  60
ALA A 319
ASN A  58
 None
 1.15A 3tm4B-5wyaA:
2.5		 3tm4B-5wyaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 LEU A 413
GLY A  60
HIS A  61
ALA A 319
ASN A  58
 None
 1.01A 3tm4B-5wyaA:
2.5		 3tm4B-5wyaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 ILE A 265
ILE A 122
ALA A 126
ASP A 274
PHE A 247
 None
 1.27A 3vw1D-5wyaA:
undetectable		 3vw1D-5wyaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 8 VAL A 397
VAL A 398
LEU A  39
ILE A  48
 None
 0.69A 3wzeA-5wyaA:
undetectable		 3wzeA-5wyaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		4 / 6 TYR A 329
LEU A 321
VAL A 278
ALA A 290
 None
 1.19A 4nkvC-5wyaA:
undetectable		 4nkvC-5wyaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 10 ASP A 117
HIS A 306
VAL A 109
PHE A 111
ALA A 311
 None
 1.30A 4twlB-5wyaA:
undetectable		 4twlB-5wyaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 411
GLN A 419
ILE A 415
VAL A 398
VAL A 397
 None
 1.46A 4yfbC-5wyaA:
0.0		 4yfbC-5wyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 411
GLN A 419
ILE A 415
VAL A 398
VAL A 397
 None
 1.45A 4yfbF-5wyaA:
0.0		 4yfbF-5wyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 411
GLN A 419
ILE A 415
VAL A 398
VAL A 397
 None
 1.45A 4yfbI-5wyaA:
0.0		 4yfbI-5wyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 411
GLN A 419
ILE A 415
VAL A 398
VAL A 397
 None
 1.46A 4yfbL-5wyaA:
undetectable		 4yfbL-5wyaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 412
ALA A  37
LEU A 407
LEU A  51
ALA A 392
 None
 1.26A 5bw4B-5wyaA:
undetectable		 5bw4B-5wyaA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 12 PRO A 411
LEU A  50
GLY A 364
ASN A 366
LEU A 420
 None
 1.24A 5emlA-5wyaA:
2.2		 5emlA-5wyaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		5 / 8 GLU A 217
GLY A 140
GLY A 154
HIS A 143
HIS A 172
 7VO  A1001 (-3.8A)
None
None
None
None
 1.47A 5f8yA-5wyaA:
undetectable		 5f8yA-5wyaA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5wya ISOLEUCINE
2-EPIMERASE
(Lactobacillus
buchneri) 		3 / 3 GLY A 340
THR A  38
PRO A 411
 None
 0.67A 5v5zA-5wyaA:
undetectable		 5v5zA-5wyaA:
21.52