SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wyb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO B 162
LEU B 164
THR B 184
ARG B 187
 None
 1.10A 1i2wA-5wybB:
undetectable		 1i2wA-5wybB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU B  55
CYH B 131
ALA B 128
CYH B 127
 None
 0.99A 1mz9D-5wybB:
undetectable		 1mz9D-5wybB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG B 134
ILE B 116
ALA B 120
LEU B 129
PHE B 102
 None
 1.22A 1og5B-5wybB:
undetectable		 1og5B-5wybB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 SER B  75
LEU B  48
LEU B  45
PHE B 102
ILE B  32
 None
 1.10A 2v0mC-5wybB:
undetectable		 2v0mC-5wybB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE B  83
LEU B 144
GLY B 124
GLY B  77
ALA B 155
 MRD  B 301 (-4.3A)
None
None
MRD  B 301 ( 4.8A)
MRD  B 301 (-4.2A)
 1.21A 3i5uA-5wybB:
undetectable		 3i5uA-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		6 / 10 LEU B  29
GLY B  25
ASP B  60
ASP B  58
VAL B 211
VAL B  65
 None
 1.47A 3oxwA-5wybB:
undetectable		 3oxwA-5wybB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 PHE B  74
ILE B  32
GLY B 123
CYH B 127
 None
None
MRD  B 301 (-3.4A)
None
 1.31A 3r0lD-5wybB:
undetectable		 3r0lD-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA B  78
GLU B 126
GLU B 146
ALA B 155
 MRD  B 301 (-3.1A)
MRD  B 301 (-2.8A)
MRD  B 301 (-2.5A)
MRD  B 301 (-4.2A)
 0.66A 3r9tC-5wybB:
28.8		 3r9tC-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL B  65
GLY B 202
ALA B 204
ALA B 200
THR B  67
 None
ACT  B 302 ( 3.9A)
None
None
None
 1.23A 3ucjA-5wybB:
undetectable		 3ucjA-5wybB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG B  97
ARG B  96
ILE B  46
 None
 0.85A 4b7qA-5wybB:
undetectable		 4b7qA-5wybB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG B  97
ARG B  96
ILE B  46
 None
 0.85A 4b7qC-5wybB:
undetectable		 4b7qC-5wybB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER B 112
GLU B 103
GLY B 228
ARG B 230
 None
 0.92A 4fgzA-5wybB:
undetectable
4fgzB-5wybB:
undetectable		 4fgzA-5wybB:
undetectable
4fgzB-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 5 ILE B  30
PHE B 108
SER B 112
ALA B  28
 None
 1.20A 5msdA-5wybB:
undetectable		 5msdA-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS B  34
ASN B  38
ALA B  76
 None
 0.76A 5n4tB-5wybB:
2.3		 5n4tB-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL B 195
ASP B 196
GLU B 137
LEU B 206
ALA B 203
 None
None
None
None
ACT  B 302 ( 4.4A)
 1.25A 5nd3B-5wybB:
undetectable		 5nd3B-5wybB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL B 195
ASP B 196
GLU B 137
LEU B 206
ALA B 203
 None
None
None
None
ACT  B 302 ( 4.4A)
 1.31A 5nd4B-5wybB:
undetectable		 5nd4B-5wybB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 123
THR B  39
SER B  75
LEU B  64
LEU B 105
 MRD  B 301 (-3.4A)
None
None
None
None
 1.21A 5nfjC-5wybB:
undetectable		 5nfjC-5wybB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE B 113
ALA B  63
ILE B 133
THR B  27
 None
 0.92A 5uihA-5wybB:
undetectable		 5uihA-5wybB:
21.88