SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		4 / 6 HIS B  61
ASP B  47
THR B  46
TRP B  65
 None
 1.12A 2dysA-5wyhB:
undetectable
2dysC-5wyhB:
2.1		 2dysA-5wyhB:
undetectable
2dysC-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		4 / 8 PRO B  48
SER B  49
VAL B 181
GLY B 180
 None
 1.09A 2qd3A-5wyhB:
undetectable		 2qd3A-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		3 / 3 GLN B 193
GLU B 113
LYS B 117
 None
 1.23A 3su9A-5wyhB:
undetectable		 3su9A-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		5 / 10 GLY B 119
ASP B 124
ALA B 130
LEU B 120
LEU B 150
 None
 1.01A 4xj7A-5wyhB:
undetectable
4xj7B-5wyhB:
undetectable		 4xj7A-5wyhB:
13.16
4xj7B-5wyhB:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		5 / 10 LEU B 120
LEU B 150
GLY B 119
ASP B 124
ALA B 130
 None
 1.07A 4xj7C-5wyhB:
undetectable
4xj7D-5wyhB:
undetectable		 4xj7C-5wyhB:
13.16
4xj7D-5wyhB:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		3 / 3 LYS B  83
LYS B  90
SER B  91
 None
 1.16A 5odiA-5wyhB:
undetectable		 5odiA-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		4 / 6 ARG B  85
LYS B  86
LEU B  89
PHE B  94
 None
 1.20A 5x19P-5wyhB:
2.1		 5x19P-5wyhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5wyh INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ALA B 112
GLY B 160
GLY B 180
VAL B 158
ASP B  47
 None
 1.30A 6clxA-5wyhB:
undetectable		 6clxA-5wyhB:
undetectable