SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		4 / 5 TYR A  94
LEU A  81
LEU A  86
ARG A  67
 None
 1.31A 4em2A-5wymA:
undetectable		 4em2A-5wymA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.86A 5jsdA-5wymA:
2.6		 5jsdA-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.87A 5jsdB-5wymA:
undetectable		 5jsdB-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.86A 5jsdC-5wymA:
undetectable		 5jsdC-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.88A 5jseA-5wymA:
2.5		 5jseA-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.89A 5jseB-5wymA:
undetectable		 5jseB-5wymA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5wym ANTI-CONNEXIN26
SCFV,IG HEAVY
CHAIN,LINKER,ANTI-CO
NNEXIN26 SCFV,IG
LIGHT CHAIN
(Homo
sapiens;
synthetic
construct) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.88A 5jseC-5wymA:
3.0		 5jseC-5wymA:
8.46