SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 9 VAL A 131
VAL A 161
LEU A 172
ILE A 140
LEU A 222
None
1.12A 1eqgA-5wypA:
undetectable
1eqgA-5wypA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 11 VAL A 131
VAL A 161
LEU A 172
ILE A 140
LEU A 222
None
1.12A 1eqgB-5wypA:
undetectable
1eqgB-5wypA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 HIS A 162
GLY A 198
LEU A 136
LEU A 172
PRO A 190
None
1.31A 1mj2A-5wypA:
undetectable
1mj2B-5wypA:
undetectable
1mj2A-5wypA:
undetectable
1mj2B-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 HIS A 162
GLY A 198
LEU A 136
LEU A 172
PRO A 190
None
1.28A 1mj2C-5wypA:
undetectable
1mj2D-5wypA:
undetectable
1mj2C-5wypA:
undetectable
1mj2D-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 HIS A 162
GLY A 198
LEU A 136
LEU A 172
PRO A 190
None
1.27A 1mjoC-5wypA:
undetectable
1mjoD-5wypA:
undetectable
1mjoC-5wypA:
undetectable
1mjoD-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 11 LEU A 136
LEU A 172
PRO A 190
HIS A 162
GLY A 198
None
1.29A 1mjqI-5wypA:
undetectable
1mjqJ-5wypA:
undetectable
1mjqI-5wypA:
undetectable
1mjqJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
1.06A 2dysN-5wypA:
undetectable
2dysW-5wypA:
undetectable
2dysN-5wypA:
undetectable
2dysW-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 THR A 219
VAL A 131
LEU A 136
ALA A 216
None
0.95A 2e1qA-5wypA:
undetectable
2e1qA-5wypA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 THR A 219
VAL A 131
LEU A 136
ALA A 216
None
0.90A 2e1qC-5wypA:
undetectable
2e1qC-5wypA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
1.04A 2eilA-5wypA:
undetectable
2eilJ-5wypA:
undetectable
2eilA-5wypA:
undetectable
2eilJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.13A 2qk8A-5wypA:
undetectable
2qk8A-5wypA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
1.05A 2zxwA-5wypA:
undetectable
2zxwJ-5wypA:
undetectable
2zxwA-5wypA:
undetectable
2zxwJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 7 ILE A 323
PHE A 321
ARG A 345
THR A 263
None
1.05A 3ag2N-5wypA:
undetectable
3ag2W-5wypA:
undetectable
3ag2N-5wypA:
undetectable
3ag2W-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
1.07A 3asnA-5wypA:
undetectable
3asnJ-5wypA:
undetectable
3asnA-5wypA:
undetectable
3asnJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 6 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
1.08A 3asoA-5wypA:
undetectable
3asoJ-5wypA:
undetectable
3asoA-5wypA:
undetectable
3asoJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.04A 3fl9B-5wypA:
undetectable
3fl9B-5wypA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 11 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.11A 3fl9C-5wypA:
undetectable
3fl9C-5wypA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 10 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.10A 3fl9E-5wypA:
undetectable
3fl9E-5wypA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.10A 3fl9G-5wypA:
undetectable
3fl9G-5wypA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 9 ALA A  37
LEU A  89
ILE A  33
LEU A  14
PHE A  44
None
1.17A 3fl9H-5wypA:
undetectable
3fl9H-5wypA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 LEU A 298
VAL A 314
GLY A 294
LEU A 289
ILE A 323
None
1.08A 3ijdA-5wypA:
undetectable
3ijdA-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 7 THR A 219
VAL A 131
LEU A 136
ALA A 216
None
0.96A 3uniA-5wypA:
undetectable
3uniA-5wypA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 4 ALA A  13
VAL A  17
ASP A  55
LEU A 212
None
1.47A 4e7gA-5wypA:
undetectable
4e7gA-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 5 TYR A 154
THR A 177
PRO A 248
VAL A 253
None
1.16A 4mjqA-5wypA:
42.2
4mjqA-5wypA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
8 / 9 TYR A 154
THR A 177
GLY A 179
LEU A 182
PRO A 248
VAL A 253
VAL A 366
MET A 368
None
1.04A 4mjrA-5wypA:
42.0
4mjrA-5wypA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
6 / 9 TYR A 155
THR A 177
GLY A 179
LEU A 182
VAL A 253
VAL A 366
None
0.63A 4mjrA-5wypA:
42.0
4mjrA-5wypA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
3 / 3 ILE A  53
ASP A  48
ARG A 211
None
0.74A 4pstA-5wypA:
undetectable
4pstA-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 9 PHE A 231
LEU A 238
LEU A 125
VAL A 199
VAL A 201
None
1.40A 4wnvB-5wypA:
undetectable
4wnvB-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 5 ALA A   9
ARG A  41
HIS A  16
ALA A  13
None
1.17A 5a06C-5wypA:
undetectable
5a06D-5wypA:
undetectable
5a06C-5wypA:
undetectable
5a06D-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 7 LEU A 156
THR A 177
PRO A 248
MET A 368
None
1.07A 5fxtA-5wypA:
37.9
5fxtA-5wypA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 8 THR A 177
LEU A 182
PRO A 248
PRO A 352
None
0.75A 5g48A-5wypA:
37.6
5g48A-5wypA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 9 LEU A 156
THR A 177
LEU A 182
PRO A 248
PRO A 352
None
0.85A 5g48B-5wypA:
37.6
5g48B-5wypA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 5 LEU A 264
LEU A 298
PHE A 344
LEU A 330
None
0.95A 5gtrA-5wypA:
undetectable
5gtrA-5wypA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 5 ILE A 323
PHE A 321
ARG A 345
THR A 263
None
1.04A 5z84N-5wypA:
undetectable
5z84W-5wypA:
undetectable
5z84N-5wypA:
undetectable
5z84W-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 ILE A 323
ASN A 258
PHE A 346
ILE A 296
LEU A 262
None
0.99A 6dwnC-5wypA:
undetectable
6dwnC-5wypA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
5 / 12 ILE A 323
ASN A 258
PHE A 346
ILE A 296
LEU A 262
None
0.94A 6dwnD-5wypA:
undetectable
6dwnD-5wypA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 7 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
0.98A 6nmfA-5wypA:
undetectable
6nmfJ-5wypA:
undetectable
6nmfA-5wypA:
undetectable
6nmfJ-5wypA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides)
4 / 7 LEU A 289
ARG A 345
THR A 263
LEU A 264
None
0.94A 6nmpA-5wypA:
undetectable
6nmpJ-5wypA:
undetectable
6nmpA-5wypA:
undetectable
6nmpJ-5wypA:
undetectable