SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
SER A  93
PRO A  94
GLN A  95
GLY A 118
SER A 137
ILE A 138
VAL A 142
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.29A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 12 PRO A  94
GLN A  95
GLY A 118
LEU A 143
GLY A 146
PRO A 149
 SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 1.28A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  93
PRO A  94
GLN A  95
GLY A 118
LEU A 143
GLY A 145
 None
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
 1.22A 1uakA-5wyrA:
29.7		 1uakA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  81
TRP A  40
LEU A  75
ALA A  82
 None
 1.28A 2jstA-5wyrA:
undetectable
2jstB-5wyrA:
undetectable		 2jstA-5wyrA:
21.59
2jstB-5wyrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.79A 2qmmA-5wyrA:
7.3		 2qmmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.85A 2qmmA-5wyrA:
7.3
2qmmB-5wyrA:
7.2		 2qmmA-5wyrA:
undetectable
2qmmB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A  25
ALA A  29
VAL A   9
ASP A 155
VAL A 152
 None
 1.19A 2yvlC-5wyrA:
undetectable		 2yvlC-5wyrA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 TYR A  91
LEU A  92
SER A  93
PRO A  94
GLY A 118
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.35A 3axzA-5wyrA:
24.7		 3axzA-5wyrA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 244
LEU A 242
GLN A 216
GLY A 219
 None
 1.15A 3pp1A-5wyrA:
undetectable		 3pp1A-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 127
ILE A 116
GLY A  73
HIS A 131
 None
 1.17A 3r0lD-5wyrA:
undetectable		 3r0lD-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 119
PHE A  13
PRO A  14
 None
 0.69A 3zoaB-5wyrA:
undetectable		 3zoaB-5wyrA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  89
LEU A  75
ILE A 116
LEU A 115
 None
 0.87A 4mghA-5wyrA:
undetectable		 4mghA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 242
ILE A 246
ARG A 249
 None
 0.63A 4mk4B-5wyrA:
undetectable		 4mk4B-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
SER A  93
PRO A  94
GLY A 118
GLU A 121
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-4.1A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.32A 4yvgA-5wyrA:
30.2		 4yvgA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  10
ILE A 128
ILE A 123
PHE A 127
LEU A  75
 None
 1.06A 5e4dB-5wyrA:
undetectable		 5e4dB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 219
THR A 221
LEU A 242
LEU A 214
LEU A 180
 None
 1.14A 5fhzB-5wyrA:
undetectable		 5fhzB-5wyrA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A  92
PRO A  94
GLY A 118
GLY A 122
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-4.2A)
 0.75A 5o96A-5wyrA:
6.9
5o96B-5wyrA:
2.6		 5o96A-5wyrA:
undetectable
5o96B-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 PRO A  94
GLY A 118
GLY A 122
VAL A 142
LEU A 143
 SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
 0.63A 5o96G-5wyrA:
6.7
5o96H-5wyrA:
7.0		 5o96G-5wyrA:
undetectable
5o96H-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  92
GLY A 118
GLY A 122
SER A 137
LEU A 143
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.2A)
 0.71A 5twjA-5wyrA:
9.4		 5twjA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 LEU A  92
PRO A  94
GLN A  95
GLY A 118
GLY A 122
SER A 137
ILE A 138
VAL A 142
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 ( 4.1A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.22A 5wyqA-5wyrA:
32.6		 5wyqA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 ASP A 174
SER A 175
ASP A 182
HIS A 185
 None
 0.82A 5wyqB-5wyrA:
31.4		 5wyqB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		12 / 12 TYR A  91
LEU A  92
PRO A  94
GLN A  95
GLY A 118
SER A 137
ILE A 138
TYR A 141
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-4.6A)
SFG  A 400 (-3.7A)
SFG  A 400 (-2.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.6A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.24A 5wyqB-5wyrA:
31.4		 5wyqB-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 115
VAL A   9
VAL A   7
ILE A  20
 None
 0.64A 5y9mX-5wyrA:
undetectable		 5y9mX-5wyrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 ARG A 159
SER A 175
ASP A 182
HIS A 185
 None
 0.53A 5zhmA-5wyrA:
25.8		 5zhmA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 229
LEU A 180
ARG A 232
 None
 0.67A 6fgdA-5wyrA:
2.5		 6fgdA-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  25
VAL A   7
LEU A  35
LEU A 161
 None
 0.57A 6g9bA-5wyrA:
undetectable
6g9bB-5wyrA:
undetectable		 6g9bA-5wyrA:
25.68
6g9bB-5wyrA:
14.29