SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 129
ASP A  98
SER A 101
SER A   7
 None
 1.43A 1kiaB-5wz4A:
undetectable		 1kiaB-5wz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 129
ASP A  98
SER A 101
SER A   7
 None
 1.44A 1kiaC-5wz4A:
undetectable		 1kiaC-5wz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  97
ASP A  98
GLU A  43
 None
 0.58A 2qeuA-5wz4A:
undetectable		 2qeuA-5wz4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  97
ASP A  98
GLU A  43
 None
 0.60A 2qeuC-5wz4A:
undetectable		 2qeuC-5wz4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		5 / 10 SER A 101
ALA A   5
ALA A 113
GLU A 127
ALA A 115
 None
 1.40A 2r2vC-5wz4A:
undetectable
2r2vF-5wz4A:
undetectable
2r2vG-5wz4A:
undetectable		 2r2vC-5wz4A:
18.10
2r2vF-5wz4A:
18.10
2r2vG-5wz4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5wz4 23S RRNA-SPECIFIC
ENDONUCLEASE VAPC20
(Mycobacterium
tuberculosis) 		3 / 3 HIS A  20
ASN A  14
ALA A  56
 None
CSO  A  52 ( 3.2A)
CSO  A  52 ( 3.6A)
 0.79A 5n4tB-5wz4A:
undetectable		 5n4tB-5wz4A:
22.88