SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 8 CYH A 263
GLY A 222
GLY A 223
TYR A 186
 None
 0.84A 1ekjA-5wzeA:
undetectable
1ekjB-5wzeA:
undetectable		 1ekjA-5wzeA:
undetectable
1ekjB-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 7 CYH A 263
GLY A 222
GLY A 223
TYR A 186
 None
 0.85A 1ekjE-5wzeA:
undetectable
1ekjF-5wzeA:
undetectable		 1ekjE-5wzeA:
undetectable
1ekjF-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 8 CYH A 263
GLY A 222
GLY A 223
TYR A 186
 None
 0.82A 1ekjG-5wzeA:
undetectable
1ekjH-5wzeA:
undetectable		 1ekjG-5wzeA:
undetectable
1ekjH-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 4 PHE A 137
ASP A  47
PHE A  50
VAL A  62
 None
 1.50A 1w0fA-5wzeA:
undetectable		 1w0fA-5wzeA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 5 ALA A 104
TYR A 102
ALA A 107
GLN A  46
 None
 0.81A 1xl6A-5wzeA:
undetectable
1xl6B-5wzeA:
undetectable		 1xl6A-5wzeA:
17.05
1xl6B-5wzeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 173
ASP A 362
ALA A 228
GLU A 264
ARG A  45
 None
 1.35A 2cmlA-5wzeA:
undetectable		 2cmlA-5wzeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 173
ASP A 362
ALA A 228
GLU A 264
ARG A  45
 None
 1.39A 2cmlD-5wzeA:
undetectable		 2cmlD-5wzeA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 351
GLU A 384
ALA A 313
ALA A 300
 None
MN  A 508 ( 2.3A)
None
None
 1.05A 2ejfA-5wzeA:
undetectable		 2ejfA-5wzeA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.10A 2xdcC-5wzeA:
undetectable
2xdcD-5wzeA:
undetectable		 2xdcC-5wzeA:
undetectable
2xdcD-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.17A 2xdcE-5wzeA:
undetectable
2xdcF-5wzeA:
undetectable		 2xdcE-5wzeA:
undetectable
2xdcF-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 318
ASN A 311
TRP A 310
 None
 1.05A 2y00B-5wzeA:
undetectable		 2y00B-5wzeA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.12A 2y5mE-5wzeA:
undetectable
2y5mF-5wzeA:
undetectable		 2y5mE-5wzeA:
undetectable
2y5mF-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.13A 2y6nC-5wzeA:
undetectable
2y6nD-5wzeA:
undetectable		 2y6nC-5wzeA:
undetectable
2y6nD-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.12A 2y6nE-5wzeA:
undetectable
2y6nF-5wzeA:
undetectable		 2y6nE-5wzeA:
undetectable
2y6nF-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 357
ARG A 173
ASP A 410
GLY A 262
ARG A  45
 None
 1.25A 3k13B-5wzeA:
undetectable		 3k13B-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 357
ARG A 173
ASP A 410
GLY A 262
ARG A  45
 None
 1.25A 3k13C-5wzeA:
undetectable		 3k13C-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 372
VAL A 374
TRP A 310
 None
 1.23A 3zq8C-5wzeA:
undetectable
3zq8D-5wzeA:
undetectable		 3zq8C-5wzeA:
undetectable
3zq8D-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  47
SER A  48
ASP A 359
GLU A 264
TYR A  34
 None
 1.40A 4dfuA-5wzeA:
0.6		 4dfuA-5wzeA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_B_KANB402_1
(APH(2')-ID)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  47
SER A  48
ASP A 359
GLU A 264
TYR A  34
 None
 1.38A 4dfuB-5wzeA:
0.4		 4dfuB-5wzeA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 258
ILE A 232
SER A 270
LEU A 242
ILE A 407
 None
None
None
PRO  A 504 ( 4.4A)
None
 1.07A 4dm8A-5wzeA:
undetectable		 4dm8A-5wzeA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  61
PRO A  59
TYR A  74
LEU A  76
 None
 1.06A 4iomA-5wzeA:
undetectable		 4iomA-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 5 SER A 231
GLY A 230
GLU A 216
PHE A 219
 None
 1.25A 4r82A-5wzeA:
undetectable
4r82B-5wzeA:
undetectable		 4r82A-5wzeA:
undetectable
4r82B-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 168
GLU A  21
LEU A  16
ALA A  26
SER A  24
 None
 1.19A 4wnuA-5wzeA:
undetectable		 4wnuA-5wzeA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 272
GLY A 262
ASP A 410
GLU A 384
THR A 422
 None
None
None
MN  A 508 ( 2.3A)
None
 1.35A 4xt7A-5wzeA:
undetectable		 4xt7A-5wzeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 405
TYR A 290
GLN A 286
 None
 0.73A 5qgkA-5wzeA:
undetectable		 5qgkA-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 405
TYR A 290
GLN A 286
 None
 0.69A 5qgrA-5wzeA:
undetectable		 5qgrA-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 405
TYR A 290
GLN A 286
 None
 0.68A 5qgtA-5wzeA:
undetectable		 5qgtA-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		5 / 12 GLU A   8
LEU A  65
LEU A  53
LEU A 169
ALA A  15
 None
 1.02A 5v0vA-5wzeA:
undetectable		 5v0vA-5wzeA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_2
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 4 ASP A  47
PRO A  59
GLU A  58
TYR A 102
 None
 1.19A 5xprA-5wzeA:
0.7		 5xprA-5wzeA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 366
HIS A 354
MET A 381
 ALA  A 505 (-3.8A)
MN  A 508 (-3.5A)
None
 1.14A 6af6A-5wzeA:
undetectable		 6af6A-5wzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5wze AMINOPEPTIDASE P
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 297
VAL A 383
VAL A 420
THR A 422
 None
 1.28A 6f32B-5wzeA:
undetectable		 6f32B-5wzeA:
undetectable