SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5wzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 400
SER A 399
LEU A 394
LEU A 444
HIS A 465
 U  B   5 ( 3.2A)
U  B   5 ( 4.3A)
None
None
None
 1.27A 1a8uA-5wzkA:
undetectable		 1a8uA-5wzkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 10 GLY A 400
SER A 399
LEU A 394
LEU A 444
HIS A 465
 U  B   5 ( 3.2A)
U  B   5 ( 4.3A)
None
None
None
 1.30A 1a8uB-5wzkA:
undetectable		 1a8uB-5wzkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 4 ILE A 475
LEU A 444
VAL A 427
ILE A 437
 None
 0.94A 1fm6D-5wzkA:
undetectable		 1fm6D-5wzkA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.43A 1fo4A-5wzkA:
undetectable		 1fo4A-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 TRP A 456
PHE A 443
TRP A 458
 None
 1.44A 1r15C-5wzkA:
undetectable		 1r15C-5wzkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 TRP A 456
PHE A 443
TRP A 458
 None
 1.43A 1r15F-5wzkA:
undetectable		 1r15F-5wzkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 TRP A 456
PHE A 443
TRP A 458
 None
 1.45A 1r15G-5wzkA:
undetectable		 1r15G-5wzkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 TRP A 456
PHE A 443
TRP A 458
 None
 1.44A 1r15H-5wzkA:
undetectable		 1r15H-5wzkA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 12 LEU A 141
ILE A 157
SER A 160
ILE A 204
ILE A 167
 None
 1.31A 2efjA-5wzkA:
undetectable		 2efjA-5wzkA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 7 GLU A 421
TRP A 383
PRO A 388
GLY A 425
 None
 1.15A 2hs1B-5wzkA:
undetectable		 2hs1B-5wzkA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.43A 3unaA-5wzkA:
undetectable		 3unaA-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.43A 3unaB-5wzkA:
undetectable		 3unaB-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.45A 3uncA-5wzkA:
undetectable		 3uncA-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 LEU A 353
SER A 357
VAL A 401
LEU A 405
ALA A 387
 None
 1.44A 3uncB-5wzkA:
undetectable		 3uncB-5wzkA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 9 ILE A 381
MET A 382
LEU A 353
ILE A 366
ILE A 370
 None
 1.13A 3zosA-5wzkA:
2.1		 3zosA-5wzkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 8 GLY A 118
ASN A 119
PHE A 103
ILE A  99
 None
 0.93A 4j4vC-5wzkA:
undetectable		 4j4vC-5wzkA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 ARG A 125
GLU A 123
PHE A  96
 None
 0.98A 4kszA-5wzkA:
undetectable		 4kszA-5wzkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 GLU A 315
TYR A 261
GLU A 257
 None
 0.59A 4ryaA-5wzkA:
undetectable		 4ryaA-5wzkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		5 / 11 ALA A 161
GLU A 199
LEU A 201
LEU A 184
LEU A 181
 None
 1.06A 4wg0K-5wzkA:
undetectable
4wg0L-5wzkA:
undetectable
4wg0M-5wzkA:
undetectable		 4wg0K-5wzkA:
5.24
4wg0L-5wzkA:
5.24
4wg0M-5wzkA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		3 / 3 GLU A 330
HIS A 327
ASP A 359
 G  B   6 ( 3.3A)
A  B   7 ( 3.3A)
None
 0.83A 5c0oG-5wzkA:
undetectable		 5c0oG-5wzkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 8 VAL A 163
ILE A 167
ILE A 137
PHE A 156
 None
 0.95A 5hw8H-5wzkA:
undetectable		 5hw8H-5wzkA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 8 SER A 357
LEU A 393
ILE A 406
ALA A 403
 None
 0.70A 5te8B-5wzkA:
undetectable		 5te8B-5wzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 8 THR A 124
ILE A 131
ALA A 132
LEU A 141
 None
 0.74A 5te8B-5wzkA:
undetectable		 5te8B-5wzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 6 LYS A 600
ARG A 560
GLU A 561
ALA A 564
 None
 1.05A 6an0A-5wzkA:
undetectable		 6an0A-5wzkA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5wzk PUMILIO HOMOLOG 23
(Arabidopsis
thaliana) 		4 / 7 SER A 222
HIS A 223
GLY A 221
ARG A 226
 None
G  B   9 ( 3.3A)
None
C  B   8 ( 3.0A)
 1.09A 6btxA-5wzkA:
undetectable		 6btxA-5wzkA:
23.41