SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 4 HIS A 417
ALA A 467
PHE A 465
GLY A 470
 None
 1.31A 1mj2D-5x03A:
undetectable		 1mj2D-5x03A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 4 LEU A 415
PRO A 203
ILE A 446
LEU A 445
 None
 1.10A 1ya4C-5x03A:
undetectable		 1ya4C-5x03A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 LEU A 378
ILE A 379
VAL A 390
PHE A 405
PHE A 401
 None
 1.04A 2h42C-5x03A:
undetectable		 2h42C-5x03A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 LEU A 378
ILE A 379
VAL A 390
PHE A 405
PHE A 401
 None
 0.89A 3b2rA-5x03A:
undetectable		 3b2rA-5x03A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 10 LEU A 378
ALA A 450
PHE A 449
GLY A 448
ILE A 447
 None
 1.29A 3qpsA-5x03A:
undetectable		 3qpsA-5x03A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 THR A 159
LEU A 161
LEU A 351
ILE A 151
GLY A 150
 None
 1.16A 5gs4A-5x03A:
undetectable		 5gs4A-5x03A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ASP A 282
ILE A 446
PHE A 449
LEU A 399
PHE A 250
 None
None
None
None
PLP  A 501 ( 3.5A)
 1.48A 5huaA-5x03A:
undetectable		 5huaA-5x03A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 9 ALA A 268
ILE A 234
ILE A 262
THR A 244
PRO A 246
 None
 1.21A 5kr2A-5x03A:
undetectable		 5kr2A-5x03A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 9 ALA A 268
ILE A 234
ILE A 262
THR A 244
PRO A 246
 None
 1.20A 5kr2C-5x03A:
undetectable		 5kr2C-5x03A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		6 / 12 GLY A 253
GLY A 394
ILE A 255
ASN A 396
SER A 247
ILE A 446
 None
 1.45A 5wy0A-5x03A:
2.8		 5wy0A-5x03A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 10 LEU A 265
PRO A 246
SER A 247
VAL A 168
ARG A 166
 None
 1.19A 6b89A-5x03A:
0.0		 6b89A-5x03A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5x03 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 10 LEU A 265
PRO A 246
SER A 247
VAL A 168
ARG A 166
 None
 1.29A 6b89B-5x03A:
undetectable		 6b89B-5x03A:
12.39