SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		5 / 12 TYR A 316
ILE A 309
VAL A 129
ALA A 128
LEU A 289
 None
 1.33A 1udtA-5x04A:
undetectable		 1udtA-5x04A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		3 / 3 ASN A 139
HIS A 140
VAL A 106
 None
 0.90A 3elzB-5x04A:
undetectable		 3elzB-5x04A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		3 / 3 ILE A 189
SER A 219
SER A 217
 None
 0.64A 3iltH-5x04A:
undetectable		 3iltH-5x04A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		4 / 6 THR A 231
ASN A 195
GLY A 196
ILE A 240
 None
 0.90A 3w9tF-5x04A:
undetectable		 3w9tF-5x04A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		4 / 8 SER A 217
SER A 219
LEU A 356
THR A 169
 None
 0.85A 4iklA-5x04A:
undetectable
4iklB-5x04A:
undetectable		 4iklA-5x04A:
19.76
4iklB-5x04A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		5 / 9 SER A 230
GLY A 238
GLU A 235
ILE A 240
ALA A 243
 None
 1.42A 5entC-5x04A:
undetectable		 5entC-5x04A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		4 / 4 PHE A 201
MET A 133
GLN A 134
ARG A 199
 None
 1.14A 5ewzA-5x04A:
undetectable		 5ewzA-5x04A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		3 / 3 MET A 133
GLN A 134
ARG A 199
 None
 0.78A 5ewzB-5x04A:
undetectable		 5ewzB-5x04A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J31_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		4 / 4 PHE A 201
MET A 133
GLN A 134
ARG A 199
 None
 1.09A 5j31B-5x04A:
undetectable		 5j31B-5x04A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		4 / 5 PHE A 201
MET A 133
GLN A 134
ARG A 199
 None
 1.15A 5m35A-5x04A:
undetectable		 5m35A-5x04A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5x04 DODECANOYL-[ACYL-CAR
RIER-PROTEIN]
HYDROLASE,
CHLOROPLASTIC
(Umbellularia
californica) 		3 / 3 MET A 133
GLN A 134
ARG A 199
 None
 0.94A 5m36A-5x04A:
undetectable		 5m36A-5x04A:
21.30