SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 12 LEU E  31
LEU E 165
GLY E  55
HIS E  58
PHE E  19
 None
ADP  E1001 (-4.2A)
ADP  E1001 (-3.7A)
ADP  E1001 (-4.3A)
None
 1.36A 1d4fC-5x06E:
undetectable		 1d4fC-5x06E:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 12 LEU E  98
VAL E  74
LEU E 132
LEU E 133
LEU E  60
 None
 0.97A 2egvA-5x06E:
undetectable		 2egvA-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 12 LEU E  98
VAL E  74
LEU E 132
LEU E 133
LEU E  60
 None
 0.97A 2egvB-5x06E:
undetectable		 2egvB-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 7 LEU E  48
LEU E  34
SER E  28
ASN E  27
 None
 1.05A 3lm8A-5x06E:
undetectable
3lm8C-5x06E:
undetectable		 3lm8A-5x06E:
15.35
3lm8C-5x06E:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 8 LEU E  48
LEU E  34
SER E  28
ASN E  27
 None
 0.96A 3lm8B-5x06E:
undetectable
3lm8D-5x06E:
undetectable		 3lm8B-5x06E:
15.35
3lm8D-5x06E:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 8 TYR E  45
THR E 135
TYR E  47
ARG E  56
 None
None
None
ADP  E1001 (-4.1A)
 1.20A 3wipB-5x06E:
undetectable
3wipC-5x06E:
undetectable		 3wipB-5x06E:
undetectable
3wipC-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 8 TYR E  45
THR E 135
ARG E  56
LEU E 162
 None
None
ADP  E1001 (-4.1A)
None
 1.03A 3wipG-5x06E:
undetectable
3wipH-5x06E:
undetectable		 3wipG-5x06E:
undetectable
3wipH-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 8 ARG E  56
LEU E 162
TYR E  45
THR E 135
 ADP  E1001 (-4.1A)
None
None
None
 1.07A 3wipF-5x06E:
undetectable
3wipJ-5x06E:
undetectable		 3wipF-5x06E:
undetectable
3wipJ-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 6 GLN E  35
PHE E  19
PRO E  24
PHE E  22
 None
None
None
ADP  E1001 (-3.3A)
 1.25A 4fgkA-5x06E:
undetectable		 4fgkA-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 11 ILE E  46
LEU E  98
LEU E  60
ALA E  63
LEU E  38
 None
 1.04A 4p65E-5x06E:
undetectable
4p65F-5x06E:
undetectable
4p65J-5x06E:
undetectable
4p65L-5x06E:
undetectable		 4p65E-5x06E:
undetectable
4p65F-5x06E:
undetectable
4p65J-5x06E:
undetectable
4p65L-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 12 LEU E  38
ILE E  46
LEU E  98
LEU E  60
ALA E  63
 None
 1.01A 4p65B-5x06E:
undetectable
4p65D-5x06E:
undetectable
4p65I-5x06E:
undetectable
4p65J-5x06E:
undetectable		 4p65B-5x06E:
undetectable
4p65D-5x06E:
undetectable
4p65I-5x06E:
undetectable
4p65J-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		3 / 3 ARG E  82
ASP E 110
TRP E 113
 None
 0.76A 4xdqA-5x06E:
undetectable		 4xdqA-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		5 / 12 LEU E  48
LEU E  30
PHE E  19
GLU E  17
LEU E  38
 None
None
None
ADP  E1001 (-3.9A)
None
 1.20A 5iepA-5x06E:
undetectable		 5iepA-5x06E:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5x06 DNAA REGULATORY
INACTIVATOR HDA
(Escherichia
coli) 		4 / 7 PHE E  22
LEU E  60
ALA E  62
ALA E  63
 ADP  E1001 (-3.3A)
None
None
None
 0.78A 6a7jA-5x06E:
undetectable		 6a7jA-5x06E:
17.78