SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 GLY A 133
LEU A 377
THR A 376
VAL A 131
 None
 1.12A 1ekjF-5x09A:
undetectable
1ekjG-5x09A:
undetectable		 1ekjF-5x09A:
17.46
1ekjG-5x09A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 ILE A 145
LEU A 211
ILE A 389
ILE A 218
 None
 0.74A 1uwjA-5x09A:
undetectable		 1uwjA-5x09A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 SER A 251
THR A 220
GLN A 520
 None
 0.67A 2fk8A-5x09A:
undetectable		 2fk8A-5x09A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 ALA A 230
TRP A 415
LEU A 417
ALA A 231
 None
 1.29A 2jstA-5x09A:
undetectable
2jstB-5x09A:
undetectable		 2jstA-5x09A:
6.90
2jstB-5x09A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 9 ARG A 199
LEU A  76
ILE A 174
GLY A 137
ILE A 135
 None
 1.00A 2r5qA-5x09A:
undetectable		 2r5qA-5x09A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 9 ARG A 199
LEU A  76
ILE A 174
GLY A 137
ILE A 135
 None
 1.00A 2r5qC-5x09A:
undetectable		 2r5qC-5x09A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		6 / 12 VAL A 151
ASP A 134
GLY A 378
SER A 379
PRO A 180
GLY A 132
 None
ACY  A 602 ( 4.5A)
None
None
None
None
 1.39A 2v0zC-5x09A:
undetectable		 2v0zC-5x09A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 4 GLU A 158
GLY A 157
THR A 179
GLU A 156
 None
 1.24A 3e9xA-5x09A:
undetectable		 3e9xA-5x09A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 8 HIS A 426
ILE A 430
ASN A 431
PRO A 428
 None
 0.99A 3fxrA-5x09A:
undetectable		 3fxrA-5x09A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 11 GLY A 557
ASP A 501
ARG A 499
ALA A 495
GLU A 469
 None
 1.02A 3g88A-5x09A:
2.7		 3g88A-5x09A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 11 GLY A 557
ASP A 501
ARG A 499
ALA A 495
GLU A 469
 None
 1.00A 3g88B-5x09A:
2.4		 3g88B-5x09A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 557
ASP A 501
ARG A 499
ALA A 495
GLU A 469
 None
 0.96A 3g8bB-5x09A:
undetectable		 3g8bB-5x09A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A 100
ASP A 101
PHE A 102
ILE A 103
ARG A  96
 None
 1.01A 3iv6B-5x09A:
undetectable		 3iv6B-5x09A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 LYS A 198
ARG A 320
LYS A 412
 None
 1.36A 3okxA-5x09A:
undetectable		 3okxA-5x09A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ARG A 199
LEU A  76
ILE A 174
GLY A 137
ILE A 135
 None
 1.01A 4jecB-5x09A:
undetectable		 4jecB-5x09A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 LEU A 205
LYS A 202
TYR A 201
GLU A 203
 None
 0.99A 4lb2A-5x09A:
undetectable		 4lb2A-5x09A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 ILE A  88
MET A 300
ARG A 105
 None
 0.81A 4lnwA-5x09A:
undetectable		 4lnwA-5x09A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		3 / 3 ILE A  88
MET A 300
ARG A 105
 None
 0.80A 4lnxA-5x09A:
undetectable		 4lnxA-5x09A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 7 ASN A 450
VAL A 209
GLU A 208
ARG A 373
 None
 1.26A 4mv7A-5x09A:
3.5		 4mv7A-5x09A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 10 LEU A 466
LEU A 433
HIS A 426
LEU A 421
LEU A 503
 None
 1.25A 4p65A-5x09A:
undetectable
4p65B-5x09A:
undetectable
4p65F-5x09A:
undetectable
4p65H-5x09A:
undetectable		 4p65A-5x09A:
3.61
4p65B-5x09A:
4.32
4p65F-5x09A:
4.32
4p65H-5x09A:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		4 / 5 PRO A 281
LEU A 211
TYR A 324
PHE A 319
 None
 1.30A 5igjA-5x09A:
undetectable		 5igjA-5x09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 10 ARG A 199
LEU A  76
ILE A 174
GLY A 137
ILE A 135
 None
 1.03A 5kr1A-5x09A:
undetectable		 5kr1A-5x09A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A 330
GLU A 267
ARG A 105
ALA A 104
ALA A 295
 None
 1.10A 5n5dA-5x09A:
undetectable		 5n5dA-5x09A:
17.60