SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 7 THR A 101
THR A 222
SER A 219
VAL A 161
 None
 1.18A 1tv8B-5x0eA:
undetectable		 1tv8B-5x0eA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A  89
SER A  87
PHE A  20
PRO A  86
 None
 1.30A 3bjwC-5x0eA:
undetectable		 3bjwC-5x0eA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 8 PHE A  40
LEU A  80
PHE A  50
LEU A 238
 AMP  A 301 ( 4.9A)
None
AMP  A 301 (-3.8A)
None
 1.00A 3i45A-5x0eA:
undetectable		 3i45A-5x0eA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		3 / 3 THR A 101
PRO A 203
THR A 223
 None
None
SEP  A 302 (-3.9A)
 0.88A 4hivD-5x0eA:
undetectable		 4hivD-5x0eA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 7 GLU A 131
ASP A 184
ALA A 185
TYR A 103
 None
 1.14A 4zz8A-5x0eA:
undetectable		 4zz8A-5x0eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 7 PHE A  93
ALA A  57
PRO A  60
MET A 209
 None
 1.02A 5dzkD-5x0eA:
undetectable
5dzkR-5x0eA:
undetectable		 5dzkD-5x0eA:
21.71
5dzkR-5x0eA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 174
LEU A 117
PHE A 141
GLY A 180
TYR A 179
 None
 0.96A 5uxdB-5x0eA:
undetectable		 5uxdB-5x0eA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 8 HIS A  72
PHE A  50
HIS A  29
THR A 223
 AMP  A 301 ( 3.6A)
AMP  A 301 (-3.8A)
SEP  A 302 ( 4.8A)
SEP  A 302 (-3.9A)
 1.35A 5yj1G-5x0eA:
undetectable
5yj1Y-5x0eA:
undetectable		 5yj1G-5x0eA:
16.74
5yj1Y-5x0eA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5x0e FREE SERINE KINASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 110
VAL A  33
PHE A 149
GLY A 145
 None
 1.05A 6hd4B-5x0eA:
undetectable		 6hd4B-5x0eA:
17.84