SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 11 LEU A 124
VAL A 140
ILE A 282
THR A  97
ILE A  95
 None
 0.77A 1c6yA-5x0nA:
undetectable		 1c6yA-5x0nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		4 / 6 PRO A 108
MET A 106
ASP A 283
TYR A 288
 None
 1.47A 2lh8A-5x0nA:
undetectable		 2lh8A-5x0nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 10 THR A  97
PHE A 281
MET A 266
LEU A 124
ILE A 122
 None
 1.23A 3kvrA-5x0nA:
undetectable		 3kvrA-5x0nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 10 THR A  97
PHE A 281
MET A 266
LEU A 124
ILE A 122
 None
 1.23A 3kvrB-5x0nA:
undetectable		 3kvrB-5x0nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJD_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5x0n LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Vibrio
vulnificus) 		5 / 9 LEU A 267
THR A  97
ILE A 264
LEU A 110
MET A 109
 None
 1.41A 5ljdA-5x0nA:
undetectable		 5ljdA-5x0nA:
18.40