SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		6 / 12 LEU A  23
ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.69A 3qxtB-5x0tA:
20.1		 3qxtB-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		6 / 12 VAL A  21
LEU A  23
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.72A 3qxtB-5x0tA:
20.1		 3qxtB-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		6 / 12 VAL A  21
ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.85A 3qxvB-5x0tA:
19.9		 3qxvB-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.76A 3qxvD-5x0tA:
19.7		 3qxvD-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL A  21
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.73A 3qxvD-5x0tA:
19.7		 3qxvD-5x0tA:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA A  43
MET A  53
ARG A  93
VAL A 100
TYR A 124
 None
 0.79A 3qxvE-5x0tA:
16.4		 3qxvE-5x0tA:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLU A  65
PRO A  60
LYS A  62
GLU A  61
 None
 1.24A 4a7tA-5x0tA:
3.2		 4a7tA-5x0tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLU A  65
PRO A  60
LYS A  62
GLU A  61
 None
 1.28A 4a7uA-5x0tA:
3.3		 4a7uA-5x0tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 5 TYR A 115
LEU A 102
LEU A 107
ARG A  88
 None
 1.21A 4em2A-5x0tA:
undetectable		 4em2A-5x0tA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		4 / 5 GLU A 170
PHE A 168
HIS A 221
THR A 132
 None
 1.13A 6b58A-5x0tA:
undetectable		 6b58A-5x0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5x0t 6H8 FAB FRAGMENT
HEAVY CHAIN
(Mus
musculus) 		3 / 3 TRP A  66
GLU A  65
GLU A  83
 None
 0.84A 6fhwA-5x0tA:
3.9		 6fhwA-5x0tA:
20.24