SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 12 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.02A 1bsxA-5x0yO:
undetectable		 1bsxA-5x0yO:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 12 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.02A 1bsxB-5x0yO:
undetectable		 1bsxB-5x0yO:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 6 MET O1294
LEU O1099
GLU O1293
LEU O1096
 None
 0.99A 1etb1-5x0yO:
undetectable		 1etb1-5x0yO:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 12 LEU O1211
PHE O1181
LEU O1091
ARG O1304
VAL O1106
 None
 1.18A 1hrkB-5x0yO:
2.6		 1hrkB-5x0yO:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 8 MET O1294
LEU O1099
GLU O1293
LEU O1096
 None
 0.96A 1sn5C-5x0yO:
undetectable		 1sn5C-5x0yO:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 4 LEU O 806
SER O 804
TYR O 808
LEU O 809
 None
 1.02A 1xz1A-5x0yO:
undetectable		 1xz1A-5x0yO:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 4 LEU O 806
SER O 804
TYR O 808
LEU O 809
 None
 1.02A 1xz3A-5x0yO:
undetectable		 1xz3A-5x0yO:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 12 ILE O1180
ILE O1108
MET O1119
LEU O1211
LEU O1096
 None
 1.21A 1xzxX-5x0yO:
undetectable		 1xzxX-5x0yO:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		3 / 3 LYS O 968
ASP O1232
ASP O1184
 None
 0.93A 2br4A-5x0yO:
3.3		 2br4A-5x0yO:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 8 TYR O 918
ASP O 917
TYR O 914
HIS O 913
 None
 1.34A 2ha2A-5x0yO:
undetectable		 2ha2A-5x0yO:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 8 LEU O 942
ARG O 684
PRO O 989
VAL O 747
 None
 0.99A 2qd2A-5x0yO:
2.5		 2qd2A-5x0yO:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		3 / 3 ASN O 687
ARG O 684
ASP O 743
 None
 0.95A 2qe6A-5x0yO:
2.0		 2qe6A-5x0yO:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		3 / 3 ASN O 687
ARG O 684
ASP O 743
 None
 0.92A 2qe6B-5x0yO:
undetectable		 2qe6B-5x0yO:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 5 GLN O1189
THR O1163
ARG O1164
ALA O1165
 None
 1.35A 2qhfA-5x0yO:
undetectable		 2qhfA-5x0yO:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 10 LEU O 842
VAL O 869
ILE O 861
GLY O 864
PRO O 818
 None
 1.12A 3el5A-5x0yO:
undetectable		 3el5A-5x0yO:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		3 / 3 ARG O1076
GLU O1120
ASP O1134
 None
 0.70A 3g2oA-5x0yO:
2.9		 3g2oA-5x0yO:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 7 VAL O1011
LEU O1287
ASN O1284
ILE O1095
 None
 0.98A 3rfmA-5x0yO:
undetectable		 3rfmA-5x0yO:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 7 LEU O 942
ARG O 684
PRO O 989
VAL O 747
 None
 1.23A 4klrA-5x0yO:
undetectable		 4klrA-5x0yO:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 5 LEU O1133
SER O1143
LEU O1172
ASN O1150
 None
 1.26A 4n09C-5x0yO:
undetectable		 4n09C-5x0yO:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		4 / 5 ASN O1060
HIS O1061
GLU O1218
THR O1213
 None
 1.29A 4p6sA-5x0yO:
undetectable		 4p6sA-5x0yO:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 12 ALA O 916
ILE O 892
ASN O 783
LEU O 809
GLY O 817
 None
 1.23A 4r38B-5x0yO:
undetectable		 4r38B-5x0yO:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2
(Saccharomyces
cerevisiae) 		5 / 10 LEU O 683
ILE O 945
ASN O 784
LEU O 987
LEU O 781
 None
 1.17A 5y7pG-5x0yO:
undetectable		 5y7pG-5x0yO:
18.67