SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		5 / 12 ILE E 179
LEU E 154
LEU E 151
LEU E 118
ILE E 120
 None
 1.18A 1fmlB-5x0zE:
undetectable		 1fmlB-5x0zE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		4 / 6 LEU E 132
VAL E 202
VAL E 161
ILE E 205
 None
 1.18A 2hyyB-5x0zE:
undetectable		 2hyyB-5x0zE:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		4 / 6 LEU E 132
VAL E 202
VAL E 161
ILE E 205
 None
 1.23A 3k5vB-5x0zE:
undetectable		 3k5vB-5x0zE:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		5 / 12 LEU E 154
LEU E 153
MET E  75
ILE E 120
ILE E 124
 None
 1.15A 4j24A-5x0zE:
undetectable		 4j24A-5x0zE:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		5 / 12 LEU E 154
LEU E 153
MET E  75
ILE E 120
ILE E 124
 None
 1.13A 4j24B-5x0zE:
undetectable		 4j24B-5x0zE:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		4 / 7 CYH E 217
ILE E 216
PRO E 219
ILE E 191
 None
 0.94A 4w5oA-5x0zE:
undetectable		 4w5oA-5x0zE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		4 / 7 CYH E 217
ILE E 216
PRO E 219
ILE E 191
 None
 0.93A 4z4eA-5x0zE:
undetectable		 4z4eA-5x0zE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)
(Helicobacter
pylori) 		4 / 7 CYH E 217
ILE E 216
PRO E 219
ILE E 191
 None
 0.94A 4z4gA-5x0zE:
undetectable		 4z4gA-5x0zE:
13.54