SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 186
THR A 115
TYR A 116
GLN A 108
 None
None
GOL  A 402 (-4.5A)
None
 1.49A 1eiiA-5x18A:
undetectable		 1eiiA-5x18A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 321
HIS A 226
ILE A 227
SER A 236
 None
 1.11A 1kb9A-5x18A:
undetectable
1kb9C-5x18A:
1.9
1kb9D-5x18A:
undetectable
1kb9E-5x18A:
undetectable		 1kb9A-5x18A:
20.98
1kb9C-5x18A:
20.73
1kb9D-5x18A:
21.47
1kb9E-5x18A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 8 MET A 258
ASP A 256
TYR A 331
HIS A 180
 None
 1.16A 2bteA-5x18A:
undetectable		 2bteA-5x18A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 8 MET A 258
ASP A 256
TYR A 331
HIS A 180
 None
 1.18A 2bteD-5x18A:
undetectable		 2bteD-5x18A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 110
GLU A 112
ASN A 120
ALA A 128
 None
GOL  A 402 (-2.8A)
None
None
 1.49A 2ejfB-5x18A:
undetectable		 2ejfB-5x18A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 317
VAL A 299
PHE A 266
GLU A 259
 None
 1.36A 3n61A-5x18A:
undetectable
3n61B-5x18A:
undetectable		 3n61A-5x18A:
20.60
3n61B-5x18A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 299
VAL A 317
SER A 319
 None
 0.73A 3n8xB-5x18A:
undetectable		 3n8xB-5x18A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 113
THR A 115
PHE A 212
LEU A 109
 None
 1.48A 3qelC-5x18A:
undetectable		 3qelC-5x18A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 149
LEU A 152
LEU A 355
ILE A 207
GLN A 171
 None
 1.26A 4f4dA-5x18A:
undetectable		 4f4dA-5x18A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 189
ASP A 257
ASP A 256
ILE A 185
GLU A 251
 None
 1.28A 4i41A-5x18A:
22.9		 4i41A-5x18A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 212
TYR A 186
LEU A 179
THR A 122
 None
 1.07A 4paeA-5x18A:
undetectable		 4paeA-5x18A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		6 / 11 ILE A  75
ALA A  96
LYS A  98
GLU A 112
LEU A 195
ASP A 211
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 402 (-2.8A)
None
None
 0.76A 4qmsA-5x18A:
12.6		 4qmsA-5x18A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		6 / 11 ILE A  75
ALA A  96
LYS A  98
LEU A 145
LEU A 195
ASP A 211
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 401 (-3.6A)
None
None
 0.61A 4qmsA-5x18A:
12.6		 4qmsA-5x18A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  75
ALA A  96
LYS A  98
ILE A 210
LEU A 144
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 402 ( 4.0A)
GOL  A 401 (-4.3A)
 1.00A 4rz7A-5x18A:
7.6		 4rz7A-5x18A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  75
ALA A  96
LYS A  98
LEU A 144
LEU A 195
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 401 (-4.3A)
None
 0.74A 4rz7A-5x18A:
7.6		 4rz7A-5x18A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 170
ILE A 125
ILE A 210
ASN A 193
HIS A 208
 None
None
GOL  A 402 ( 4.0A)
None
None
 1.11A 4xueA-5x18A:
undetectable		 4xueA-5x18A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 100
LYS A  98
ASN A 138
 None
GOL  A 402 (-3.2A)
None
 1.06A 4y1dA-5x18A:
undetectable
4y1dD-5x18A:
undetectable		 4y1dA-5x18A:
21.55
4y1dD-5x18A:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		5 / 10 ARG A 254
ARG A 219
LEU A 119
ILE A 118
ALA A 181
 GOL  A 403 (-3.8A)
GOL  A 403 (-3.7A)
None
None
GOL  A 403 (-3.4A)
 1.12A 4z69I-5x18A:
undetectable		 4z69I-5x18A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5x18 CASEIN KINASE I
HOMOLOG 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 261
LEU A 314
PHE A 265
LEU A 335
 None
 1.00A 5gs4A-5x18A:
undetectable		 5gs4A-5x18A:
20.39