SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5x1e ICMS
ICMW
ICMO (DOTL)
(Legionella
pneumophila;
Legionella
pneumophila;
Legionella
pneumophila) 		4 / 7 LEU B 131
LEU A  87
MET C 712
LEU C 733
 None
 1.06A 1kt3A-5x1eB:
undetectable		 1kt3A-5x1eB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5x1e ICMO (DOTL)
ICMW
(Legionella
pneumophila) 		4 / 6 ILE C 767
ARG C 761
ILE B  73
PHE B  70
 None
 1.08A 2q72A-5x1eC:
undetectable		 2q72A-5x1eC:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5x1e ICMS
(Legionella
pneumophila) 		5 / 12 ALA A  46
LEU A  58
PHE A  76
ALA A  60
GLY A  37
 None
 1.07A 2ve3A-5x1eA:
undetectable		 2ve3A-5x1eA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5x1e ICMO (DOTL)
ICMS
ICMW
(Legionella
pneumophila) 		5 / 12 LEU A  54
LEU A  84
VAL A  83
PHE C 678
PHE B 135
 None
 1.26A 2weyA-5x1eA:
undetectable		 2weyA-5x1eA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5x1e ICMS
ICMW
(Legionella
pneumophila;
Legionella
pneumophila) 		4 / 8 GLN A  98
ASP A  91
TYR B 138
CYH B 136
 None
 1.31A 2xz5A-5x1eA:
undetectable
2xz5C-5x1eA:
undetectable		 2xz5A-5x1eA:
16.51
2xz5C-5x1eA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5x1e ICMO (DOTL)
ICMW
(Legionella
pneumophila) 		4 / 6 ARG C 771
LYS B  58
VAL B  92
LEU B  61
 None
 0.67A 4em2A-5x1eC:
undetectable		 4em2A-5x1eC:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x1e ICMS
ICMW
(Legionella
pneumophila;
Legionella
pneumophila) 		4 / 6 MET A   9
ILE A  42
ARG A  45
VAL B 134
 None
 1.37A 4mk4B-5x1eA:
undetectable		 4mk4B-5x1eA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5x1e ICMS
(Legionella
pneumophila) 		5 / 12 ILE A  97
THR A 106
LEU A  96
LEU A 108
PHE A  33
 None
 1.40A 4pbhA-5x1eA:
undetectable		 4pbhA-5x1eA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5x1e ICMS
ICMO (DOTL)
(Legionella
pneumophila;
Legionella
pneumophila) 		5 / 12 LEU C 733
VAL A  83
PRO A  81
THR A  80
ARG A  85
 None
 1.33A 4q15A-5x1eC:
undetectable		 4q15A-5x1eC:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5x1e ICMS
ICMO (DOTL)
(Legionella
pneumophila;
Legionella
pneumophila) 		5 / 12 LEU C 733
VAL A  83
PRO A  81
THR A  80
ARG A  85
 None
 1.31A 4q15B-5x1eC:
undetectable		 4q15B-5x1eC:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5x1e ICMS
(Legionella
pneumophila) 		4 / 5 ARG A  85
GLY A  59
ALA A  60
GLY A  57
 None
 0.82A 4u9uA-5x1eA:
undetectable		 4u9uA-5x1eA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5x1e ICMS
(Legionella
pneumophila) 		4 / 5 ARG A  85
GLY A  59
ALA A  60
GLY A  57
 None
 0.78A 4u9uB-5x1eA:
undetectable		 4u9uB-5x1eA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5x1e ICMS
(Legionella
pneumophila) 		4 / 7 LEU A  22
ALA A  41
LEU A  70
ILE A  42
 None
 0.77A 4ubsA-5x1eA:
undetectable		 4ubsA-5x1eA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5x1e ICMO (DOTL)
ICMS
ICMW
(Legionella
pneumophila) 		5 / 12 CYH A  50
LEU A  49
LEU A  84
LEU B 131
ALA C 740
 None
 1.09A 4x1iD-5x1eA:
undetectable		 4x1iD-5x1eA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5x1e ICMW
(Legionella
pneumophila) 		5 / 12 ASP B   3
THR B  26
GLY B  80
SER B  79
SER B   5
 None
 1.17A 5hfjF-5x1eB:
undetectable		 5hfjF-5x1eB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5x1e ICMW
(Legionella
pneumophila) 		4 / 8 ILE B  71
ARG B  72
PRO B 114
ALA B 115
 None
 1.00A 5m0oC-5x1eB:
undetectable		 5m0oC-5x1eB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 5x1e ICMS
ICMW
(Legionella
pneumophila;
Legionella
pneumophila) 		4 / 5 ASP A  91
ARG B 139
ARG B 133
LEU A 108
 None
 1.48A 5tuiB-5x1eA:
undetectable		 5tuiB-5x1eA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5x1e ICMO (DOTL)
ICMW
(Legionella
pneumophila) 		4 / 7 LEU C 681
TYR C 743
GLU B  32
SER B  79
 None
 1.17A 5umwA-5x1eC:
undetectable
5umwF-5x1eC:
undetectable		 5umwA-5x1eC:
25.66
5umwF-5x1eC:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5x1e ICMO (DOTL)
ICMW
(Legionella
pneumophila) 		4 / 7 LEU C 702
TYR C 743
GLU B  32
SER B  79
 None
 1.27A 5umwA-5x1eC:
undetectable
5umwF-5x1eC:
undetectable		 5umwA-5x1eC:
25.66
5umwF-5x1eC:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5x1e ICMS
ICMO (DOTL)
(Legionella
pneumophila;
Legionella
pneumophila) 		5 / 12 LEU C 733
VAL A  83
PRO A  81
THR A  80
ARG A  85
 None
 1.38A 5xipD-5x1eC:
undetectable		 5xipD-5x1eC:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5x1e ICMW
(Legionella
pneumophila) 		3 / 3 ARG B 121
PHE B 118
GLY B  75
 None
 0.73A 6fgdA-5x1eB:
undetectable		 6fgdA-5x1eB:
17.63