SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 9 LEU A 146
VAL A 273
VAL A 232
GLY A 230
LEU A 295
 None
 1.30A 1lwfA-5x1tA:
undetectable		 1lwfA-5x1tA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		3 / 3 PHE A  23
TRP A 108
GLU A 110
 None
 1.12A 1mogA-5x1tA:
undetectable		 1mogA-5x1tA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 VAL A  37
ALA A  50
LEU A 102
THR A 118
HIS A 163
SER A 186
 ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
None
 1.02A 1uwjA-5x1tA:
22.7		 1uwjA-5x1tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 ILE A  29
VAL A  37
ALA A  50
LEU A 102
THR A 118
HIS A 163
 None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
 1.04A 1uwjB-5x1tA:
22.6		 1uwjB-5x1tA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 12 ILE A 288
LEU A 233
ILE A 171
ASN A 170
LEU A 181
 None
 1.17A 2w3bB-5x1tA:
undetectable		 2w3bB-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 12 ALA A  50
LEU A 101
THR A 118
PHE A 120
HIS A 163
 ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
ADP  A 401 ( 4.2A)
None
 0.59A 3cs9C-5x1tA:
21.1		 3cs9C-5x1tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 12 ALA A  50
LEU A 101
THR A 118
PHE A 120
HIS A 163
 ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
ADP  A 401 ( 4.2A)
None
 0.53A 3cs9D-5x1tA:
20.2		 3cs9D-5x1tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 12 VAL A  37
ALA A  50
THR A 118
ILE A 156
HIS A 163
 ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
ADP  A 401 (-4.1A)
None
None
 0.85A 3gcsA-5x1tA:
19.3		 3gcsA-5x1tA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 ILE A  29
VAL A  37
ALA A  50
LYS A  52
LEU A  93
THR A 118
 None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
None
ADP  A 401 (-4.1A)
 1.04A 3og7A-5x1tA:
21.8		 3og7A-5x1tA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 9 LEU A 126
ASP A 183
ILE A 153
PRO A 179
ILE A 173
 None
 1.05A 3s56B-5x1tA:
undetectable		 3s56B-5x1tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
ASP A 183
 None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
None
 1.11A 4xv2A-5x1tA:
22.1		 4xv2A-5x1tA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 6 ASP A 225
PRO A 241
THR A 235
VAL A 232
 None
 1.10A 4yoaA-5x1tA:
undetectable		 4yoaA-5x1tA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 4 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.11A 4zzbC-5x1tA:
1.3		 4zzbC-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 4 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.16A 4zzcC-5x1tA:
1.4		 4zzcC-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 4 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.12A 4zzcD-5x1tA:
1.5		 4zzcD-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 5 ILE A  51
ILE A  36
ARG A  62
TYR A 115
 None
 1.13A 4zzcE-5x1tA:
undetectable		 4zzcE-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 12 VAL A  37
ALA A  50
LYS A  52
LEU A  93
THR A 118
 ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
None
ADP  A 401 (-4.1A)
 0.86A 5cswB-5x1tA:
21.8		 5cswB-5x1tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.33A 5hieA-5x1tA:
7.5		 5hieA-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.34A 5hieB-5x1tA:
7.5		 5hieB-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 GLY A  30
GLY A  35
VAL A  37
ALA A  50
LEU A 102
THR A 118
 ADP  A 401 (-3.4A)
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.20A 5hieC-5x1tA:
21.4		 5hieC-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.32A 5hieC-5x1tA:
21.4		 5hieC-5x1tA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		6 / 12 GLY A  35
PHE A  86
VAL A  37
ALA A  50
LEU A 102
THR A 118
 None
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
ADP  A 401 (-4.1A)
 1.33A 5hieD-5x1tA:
21.4		 5hieD-5x1tA:
13.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		5 / 9 ILE A  29
GLY A  30
VAL A  37
ALA A  50
LEU A 182
 None
ADP  A 401 (-3.4A)
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
ADP  A 401 ( 4.2A)
 0.56A 5lw1B-5x1tA:
21.1		 5lw1B-5x1tA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 8 TYR A 227
THR A 224
ARG A 164
GLN A 220
 None
 1.35A 5tzoB-5x1tA:
undetectable		 5tzoB-5x1tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 8 TYR A 227
THR A 224
ARG A 164
GLN A 220
 None
 1.32A 5tzoC-5x1tA:
undetectable		 5tzoC-5x1tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 9 HIS A 157
ILE A 153
ILE A 171
ILE A 173
 None
 0.76A 5vkqB-5x1tA:
undetectable
5vkqC-5x1tA:
undetectable		 5vkqB-5x1tA:
undetectable
5vkqC-5x1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5x1t PPKA-294
(Serratia
sp.
FS14) 		4 / 7 GLY A  35
ILE A  68
GLN A  80
TYR A 115
 None
 1.05A 5vlmC-5x1tA:
undetectable		 5vlmC-5x1tA:
undetectable