SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 ALA A 282
VAL A 284
TRP A 212
 None
 0.72A 1bdwA-5x1uA:
undetectable
1bdwB-5x1uA:
undetectable		 1bdwA-5x1uA:
9.77
1bdwB-5x1uA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 LEU A 285
MET A 319
MET A 230
 None
 1.03A 2vavF-5x1uA:
undetectable		 2vavF-5x1uA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 VAL A 323
VAL A 301
PHE A 229
GLU A 293
 None
 1.35A 3n61A-5x1uA:
undetectable
3n61B-5x1uA:
undetectable		 3n61A-5x1uA:
21.96
3n61B-5x1uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 ARG A 315
LEU A 316
SER A 219
LEU A 285
LEU A 225
 None
 1.22A 4or0A-5x1uA:
undetectable		 4or0A-5x1uA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 ARG A 315
LEU A 316
SER A 219
LEU A 285
LEU A 225
 None
 1.22A 4or0B-5x1uA:
undetectable		 4or0B-5x1uA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 9 ALA A 231
VAL A 277
SER A 271
LEU A 273
VAL A 274
 None
 1.41A 4z69A-5x1uA:
undetectable		 4z69A-5x1uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5x1u UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 VAL A 301
PRO A 210
VAL A 332
PHE A 306
PHE A 229
 None
 1.38A 6becA-5x1uA:
undetectable
6becB-5x1uA:
undetectable
6becC-5x1uA:
undetectable		 6becA-5x1uA:
16.35
6becB-5x1uA:
16.35
6becC-5x1uA:
16.35