SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 5x1x MUTATOR MUTT PROTEIN
(Staphylococcus
aureus) 		4 / 8 PRO A  36
ILE A  11
ILE A  12
ILE A  54
 None
 0.78A 3p4wC-5x1xA:
undetectable		 3p4wC-5x1xA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5x1x MUTATOR MUTT PROTEIN
(Staphylococcus
aureus) 		4 / 6 ILE A 126
ILE A 102
TRP A 104
TRP A  33
 None
 1.44A 3welA-5x1xA:
undetectable		 3welA-5x1xA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5x1x MUTATOR MUTT PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A  11
ALA A  10
ALA A  21
ARG A  23
PHE A  13
 None
 1.45A 4zo1X-5x1xA:
undetectable		 4zo1X-5x1xA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5x1x MUTATOR MUTT PROTEIN
(Staphylococcus
aureus) 		4 / 7 PRO A  36
ILE A  11
ILE A  12
ILE A  54
 None
 0.78A 5murB-5x1xA:
undetectable		 5murB-5x1xA:
19.20