SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 5 GLY B 436
LEU B 437
THR B 438
VAL B 504
 None
 0.98A 1ekjF-5x1yB:
undetectable
1ekjG-5x1yB:
undetectable		 1ekjF-5x1yB:
18.94
1ekjG-5x1yB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 6 LEU B 277
GLY B 265
LEU B 342
ILE B 260
 None
None
None
FAD  B 601 ( 3.8A)
 0.91A 1yajF-5x1yB:
undetectable		 1yajF-5x1yB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.02A 2br4A-5x1yB:
3.4		 2br4A-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.07A 2br4D-5x1yB:
3.4		 2br4D-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.04A 2br4E-5x1yB:
3.0		 2br4E-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 354
GLU B 114
GLY B  91
ALA B 218
ALA B 385
 FAD  B 601 (-4.6A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.3A)
FAD  B 601 ( 4.6A)
None
 1.05A 2br4F-5x1yB:
3.2		 2br4F-5x1yB:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 THR B 121
ILE B  90
GLY B  91
GLY B  93
GLY B 111
 FAD  B 601 (-3.5A)
FAD  B 601 (-4.9A)
FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
None
 0.87A 2fk8A-5x1yB:
2.5		 2fk8A-5x1yB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 11 GLY B 220
THR B 219
THR B 121
ARG B 115
GLY B  93
 FAD  B 601 (-3.1A)
FAD  B 601 (-3.9A)
FAD  B 601 (-3.5A)
FAD  B 601 (-3.1A)
FAD  B 601 (-3.2A)
 1.18A 2fn1B-5x1yB:
undetectable		 2fn1B-5x1yB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY B 402
GLY B  91
GLY B  93
SER B  98
ILE B  90
 None
FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
None
FAD  B 601 (-4.9A)
 1.16A 2wa2A-5x1yB:
undetectable		 2wa2A-5x1yB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 PHE B 268
LEU B 271
PRO B 147
GLY B 137
LEU B 267
 None
 1.07A 3e23A-5x1yB:
2.6		 3e23A-5x1yB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY B 403
GLY B 402
ALA B 385
ALA B 103
ILE B 417
 None
 1.11A 3jayA-5x1yB:
undetectable		 3jayA-5x1yB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 133
ILE B 248
PRO B 249
SER B 273
LEU B 163
 None
 1.02A 3nrrA-5x1yB:
undetectable		 3nrrA-5x1yB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 6 THR B 117
GLY B 119
ASN B 124
GLY B 220
 None
None
None
FAD  B 601 (-3.1A)
 0.90A 4fjpA-5x1yB:
undetectable		 4fjpA-5x1yB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 7 THR B 117
GLY B 119
ASN B 124
GLY B 220
 None
None
None
FAD  B 601 (-3.1A)
 0.83A 4forA-5x1yB:
undetectable		 4forA-5x1yB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 THR B 428
VAL B 432
VAL B 254
GLN B 279
ILE B 260
 None
None
None
None
FAD  B 601 ( 3.8A)
 1.35A 4s0vA-5x1yB:
undetectable		 4s0vA-5x1yB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 4 GLY B 116
LEU B 354
PHE B 197
ILE B  90
 FAD  B 601 (-4.0A)
FAD  B 601 (-4.6A)
None
FAD  B 601 (-4.9A)
 0.83A 4xv2A-5x1yB:
undetectable		 4xv2A-5x1yB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 7 LEU B 243
PRO B 129
LEU B 264
GLU B 263
 None
None
FAD  B 601 ( 4.9A)
FAD  B 601 ( 4.5A)
 1.01A 4z4fA-5x1yB:
undetectable		 4z4fA-5x1yB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 6 VAL B 254
ARG B 280
VAL B 308
PHE B 313
 None
 1.44A 5addA-5x1yB:
undetectable
5addB-5x1yB:
undetectable		 5addA-5x1yB:
22.07
5addB-5x1yB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 6 PHE B 188
SER B  99
ALA B  96
LEU B  87
 None
 1.28A 5dzkg-5x1yB:
undetectable
5dzku-5x1yB:
undetectable		 5dzkg-5x1yB:
17.98
5dzku-5x1yB:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 9 GLY B 220
VAL B 388
ALA B 384
LEU B 216
LEU B 354
 FAD  B 601 (-3.1A)
None
None
None
FAD  B 601 (-4.6A)
 0.97A 5lw1H-5x1yB:
undetectable		 5lw1H-5x1yB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		4 / 7 LEU B 243
PRO B 129
LEU B 264
GLU B 263
 None
None
FAD  B 601 ( 4.9A)
FAD  B 601 ( 4.5A)
 1.04A 5t7bA-5x1yB:
undetectable		 5t7bA-5x1yB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 LEU B 264
LEU B 134
LEU B 133
ILE B 248
LEU B 163
 FAD  B 601 ( 4.9A)
None
None
None
None
 0.95A 5toaA-5x1yB:
undetectable		 5toaA-5x1yB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 11 GLY B  91
GLU B 114
ALA B 195
LEU B 354
ASN B 350
 FAD  B 601 (-3.3A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.8A)
FAD  B 601 (-4.6A)
FAD  B 601 ( 4.1A)
 1.20A 5x6yC-5x1yB:
undetectable		 5x6yC-5x1yB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 10 GLY B  91
GLY B  93
GLU B 114
THR B 219
ASN B 350
 FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.9A)
FAD  B 601 ( 4.1A)
 0.97A 6exiA-5x1yB:
4.1		 6exiA-5x1yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 10 GLY B  91
GLY B  93
GLU B 114
THR B 219
ASN B 350
 FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.9A)
FAD  B 601 ( 4.1A)
 1.00A 6exiB-5x1yB:
2.6		 6exiB-5x1yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY B  91
GLY B  93
GLU B 114
THR B 219
ASN B 350
 FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.9A)
FAD  B 601 ( 4.1A)
 1.00A 6exiC-5x1yB:
3.3
6exiD-5x1yB:
4.2		 6exiC-5x1yB:
10.62
6exiD-5x1yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 GLY B  91
GLY B  93
GLU B 114
THR B 219
ASN B 350
 FAD  B 601 (-3.3A)
FAD  B 601 (-3.2A)
FAD  B 601 (-2.6A)
FAD  B 601 (-3.9A)
FAD  B 601 ( 4.1A)
 0.97A 6exiC-5x1yB:
3.3
6exiD-5x1yB:
4.2		 6exiC-5x1yB:
10.62
6exiD-5x1yB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		5 / 12 GLU B 114
GLY B 119
GLY B 120
ARG B 175
GLY B 126
 FAD  B 601 (-2.6A)
None
FAD  B 601 (-3.5A)
None
FAD  B 601 (-3.3A)
 1.04A 6gneB-5x1yB:
4.4		 6gneB-5x1yB:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5x1y MERCURIC REDUCTASE
(Lysinibacillus
sphaericus) 		3 / 3 THR B 153
GLU B 138
ASN B 146
 None
 0.85A 6nj9K-5x1yB:
undetectable		 6nj9K-5x1yB:
24.78