SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		6 / 12 PHE A 411
ILE A 376
ALA A 375
ALA A 371
THR A 181
VAL A 160
 None
 1.46A 1cbsA-5x2qA:
undetectable		 1cbsA-5x2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 GLY A 429
ALA A 371
GLY A 163
ALA A 372
HIS A 183
 None
None
GLY  A 951 (-4.9A)
None
None
 1.04A 1gtnL-5x2qA:
undetectable
1gtnV-5x2qA:
undetectable		 1gtnL-5x2qA:
10.77
1gtnV-5x2qA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 6 LEU A 114
VAL A 369
ILE A  36
MET A 153
 None
 1.04A 1opjB-5x2qA:
undetectable		 1opjB-5x2qA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		3 / 3 HIS A 105
ASP A  99
ASN A 349
 None
None
NAG  A 904 (-1.9A)
 0.67A 1wg8B-5x2qA:
undetectable		 1wg8B-5x2qA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 5 LEU A 431
ASP A 289
GLY A 217
ALA A 191
 None
 0.88A 2aohA-5x2qA:
undetectable		 2aohA-5x2qA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		6 / 12 ILE A 376
ALA A 375
ALA A 371
PRO A 368
THR A 181
VAL A 160
 None
 1.43A 2fr3A-5x2qA:
undetectable		 2fr3A-5x2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		6 / 12 PHE A 411
ILE A 376
ALA A 375
ALA A 371
THR A 181
VAL A 160
 None
 1.39A 2fr3A-5x2qA:
undetectable		 2fr3A-5x2qA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 6 LEU A 114
VAL A 369
ILE A  36
MET A 153
 None
 1.09A 2hyyC-5x2qA:
undetectable		 2hyyC-5x2qA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.20A 2j7xA-5x2qA:
undetectable		 2j7xA-5x2qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 5 ILE A 326
LEU A 358
ALA A 329
PHE A  63
 None
 1.06A 2opxA-5x2qA:
3.2		 2opxA-5x2qA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 8 ARG A 202
SER A 452
VAL A 193
GLY A 194
 None
 0.99A 2qd3A-5x2qA:
4.3		 2qd3A-5x2qA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 6 GLY A  37
GLY A 109
GLN A 346
PHE A  71
 None
 0.86A 2qx6A-5x2qA:
4.4
2qx6B-5x2qA:
4.8		 2qx6A-5x2qA:
19.83
2qx6B-5x2qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 PHE A 248
ILE A 259
ALA A 275
THR A 242
LEU A 207
 None
 1.39A 2rctA-5x2qA:
undetectable		 2rctA-5x2qA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 8 ILE A  36
GLY A  37
LEU A 113
LEU A 114
 None
 0.87A 2vctC-5x2qA:
undetectable		 2vctC-5x2qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 LEU A 113
GLY A  94
GLY A  37
LEU A  35
LEU A  39
 None
 1.09A 3e23A-5x2qA:
undetectable		 3e23A-5x2qA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 SER A 106
HIS A 144
GLY A  37
VAL A 137
GLY A 138
 None
 1.38A 3f8wB-5x2qA:
2.4		 3f8wB-5x2qA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 8 VAL A 369
PHE A  76
TYR A 374
VAL A 137
 None
NAG  A 901 (-4.1A)
None
None
 1.15A 3fhxB-5x2qA:
undetectable		 3fhxB-5x2qA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 THR A 141
HIS A 100
ILE A  42
ILE A  64
LEU A  39
 GLY  A 951 (-4.4A)
None
None
None
None
 1.30A 3gwxA-5x2qA:
undetectable		 3gwxA-5x2qA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 8 PHE A 178
VAL A 160
ASN A 423
GLY A 424
 None
None
None
NA  A 962 ( 4.6A)
 0.66A 3hjoB-5x2qA:
undetectable		 3hjoB-5x2qA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 7 PHE A 178
VAL A 160
ASN A 423
GLY A 424
 None
None
None
NA  A 962 ( 4.6A)
 0.71A 3kmoB-5x2qA:
undetectable		 3kmoB-5x2qA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 9 PHE A 420
GLY A 135
CYH A 164
PHE A 367
PHE A 428
 None
None
GLY  A 951 (-4.7A)
None
None
 1.25A 3ko0A-5x2qA:
undetectable
3ko0C-5x2qA:
undetectable		 3ko0A-5x2qA:
12.11
3ko0C-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 8 GLY A 135
CYH A 164
PHE A 367
PHE A 428
PHE A 420
 None
GLY  A 951 (-4.7A)
None
None
None
 1.24A 3ko0D-5x2qA:
undetectable
3ko0E-5x2qA:
undetectable		 3ko0D-5x2qA:
12.11
3ko0E-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 8 PHE A 420
GLY A 135
CYH A 164
PHE A 367
PHE A 428
 None
None
GLY  A 951 (-4.7A)
None
None
 1.29A 3ko0B-5x2qA:
undetectable
3ko0J-5x2qA:
undetectable		 3ko0B-5x2qA:
12.11
3ko0J-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 7 GLY A 135
PHE A 367
PHE A 428
PHE A 420
 None
 1.16A 3ko0L-5x2qA:
undetectable
3ko0N-5x2qA:
undetectable		 3ko0L-5x2qA:
12.11
3ko0N-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 10 PHE A 420
GLY A 135
CYH A 164
PHE A 367
PHE A 428
 None
None
GLY  A 951 (-4.7A)
None
None
 1.34A 3ko0L-5x2qA:
undetectable
3ko0N-5x2qA:
undetectable		 3ko0L-5x2qA:
12.11
3ko0N-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 10 GLY A 135
CYH A 164
PHE A 367
PHE A 428
PHE A 420
 None
GLY  A 951 (-4.7A)
None
None
None
 1.35A 3ko0R-5x2qA:
undetectable
3ko0T-5x2qA:
undetectable		 3ko0R-5x2qA:
12.11
3ko0T-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 7 PHE A 420
GLY A 135
PHE A 367
PHE A 428
 None
 1.12A 3ko0R-5x2qA:
undetectable
3ko0T-5x2qA:
undetectable		 3ko0R-5x2qA:
12.11
3ko0T-5x2qA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 8 GLY A 166
PHE A 262
ILE A 189
PHE A 206
 None
 0.90A 4fglD-5x2qA:
4.5		 4fglD-5x2qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.21A 4j26A-5x2qA:
undetectable		 4j26A-5x2qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 11 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.21A 4pxmB-5x2qA:
undetectable		 4pxmB-5x2qA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 6 GLY A 166
PHE A 262
ILE A 189
PHE A 206
 None
 1.06A 4qogA-5x2qA:
4.5
4qogB-5x2qA:
4.4		 4qogA-5x2qA:
19.83
4qogB-5x2qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 6 GLY A 194
PHE A 221
ILE A 189
PHE A 206
 None
 1.10A 4qogA-5x2qA:
4.5
4qogB-5x2qA:
4.4		 4qogA-5x2qA:
19.83
4qogB-5x2qA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 PHE A 248
ILE A 259
ALA A 275
THR A 242
LEU A 207
 None
 1.40A 4qzuA-5x2qA:
undetectable		 4qzuA-5x2qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		4 / 5 SER A 161
GLY A 163
ARG A 180
PHE A 178
 None
GLY  A 951 (-4.9A)
None
None
 1.19A 4r82A-5x2qA:
undetectable
4r82B-5x2qA:
undetectable		 4r82A-5x2qA:
17.32
4r82B-5x2qA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 MET A  74
LEU A  30
LEU A  35
ILE A 376
GLY A 135
 None
 1.14A 5gtrA-5x2qA:
undetectable		 5gtrA-5x2qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 11 VAL A 188
ILE A 189
ILE A 230
ILE A 225
PHE A 206
 None
 1.15A 5hw8D-5x2qA:
undetectable		 5hw8D-5x2qA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 LEU A 406
LEU A  39
ILE A 151
ALA A 133
LEU A 114
 None
 1.18A 5ienB-5x2qA:
undetectable		 5ienB-5x2qA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 VAL A 188
ILE A 189
ILE A 225
PHE A 206
ILE A 458
 None
 1.17A 6mkeB-5x2qA:
undetectable
6mkeC-5x2qA:
undetectable		 6mkeB-5x2qA:
12.50
6mkeC-5x2qA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A
(Oryzias
latipes) 		5 / 12 PRO A 315
GLY A 290
GLY A 311
VAL A 260
ALA A 442
 None
 1.02A 6nj9K-5x2qA:
4.4		 6nj9K-5x2qA:
21.29