SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x2v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 5 LEU A 255
SER A  95
LEU A 239
GLY A 222
 None
 1.13A 1a4lB-5x2vA:
undetectable		 1a4lB-5x2vA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 10 ARG A 235
GLU A  71
ALA A  72
ALA A  75
GLY A  79
 None
 1.12A 1mjqG-5x2vA:
undetectable
1mjqH-5x2vA:
undetectable		 1mjqG-5x2vA:
12.81
1mjqH-5x2vA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 12 LEU A 332
ASN A 330
LEU A 376
GLN A 392
LEU A 394
 None
 1.44A 1nhzA-5x2vA:
undetectable		 1nhzA-5x2vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 11 HIS A 350
PRO A 351
ARG A 364
GLY A 293
GLU A 278
 None
 1.44A 3bf6H-5x2vA:
undetectable		 3bf6H-5x2vA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 11 ALA A 221
ASP A 218
GLY A 217
GLY A 215
ILE A 219
 None
None
None
LLP  A 211 ( 3.6A)
None
 1.13A 4dcmA-5x2vA:
undetectable		 4dcmA-5x2vA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 8 LEU A  67
SER A  63
THR A  37
TYR A  33
 None
 1.04A 4drjB-5x2vA:
undetectable		 4drjB-5x2vA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 4 ALA A 393
VAL A 390
ASP A 389
LEU A 376
 None
 1.11A 4e7gA-5x2vA:
undetectable		 4e7gA-5x2vA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 PRO A 159
MET A 164
TYR A 189
 None
None
LLP  A 211 ( 4.6A)
 1.09A 4qa0B-5x2vA:
3.6		 4qa0B-5x2vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 PRO A 159
MET A 164
TYR A 189
 None
None
LLP  A 211 ( 4.6A)
 1.06A 4qa0A-5x2vA:
undetectable		 4qa0A-5x2vA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		6 / 12 VAL A 185
ALA A 160
LEU A 143
ALA A 167
ASP A 168
GLY A 171
 None
 1.25A 4v04A-5x2vA:
undetectable		 4v04A-5x2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		6 / 12 VAL A 185
ALA A 160
LEU A 143
ALA A 167
ASP A 168
GLY A 171
 None
 1.22A 4v04B-5x2vA:
undetectable		 4v04B-5x2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		3 / 3 LEU A 341
TYR A 114
SER A 208
 LLP  A 211 ( 4.6A)
LLP  A 211 ( 3.5A)
LLP  A 211 ( 2.7A)
 0.84A 5iktA-5x2vA:
undetectable		 5iktA-5x2vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 6 LEU A 394
SER A 397
PHE A 328
HIS A 350
 None
 1.13A 5om3A-5x2vA:
undetectable
5om3B-5x2vA:
undetectable		 5om3A-5x2vA:
10.23
5om3B-5x2vA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 6 ARG A 265
HIS A 269
LEU A 341
SER A 214
 None
None
LLP  A 211 ( 4.6A)
LLP  A 211 ( 4.7A)
 1.09A 5syjA-5x2vA:
undetectable		 5syjA-5x2vA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		4 / 6 ARG A 265
HIS A 269
LEU A 341
SER A 214
 None
None
LLP  A 211 ( 4.6A)
LLP  A 211 ( 4.7A)
 1.13A 5syjB-5x2vA:
undetectable		 5syjB-5x2vA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5x2v L-METHIONINE
GAMMA-LYASE
(Pseudomonas
putida) 		5 / 9 LEU A 198
PRO A 192
VAL A 225
SER A 208
LEU A 213
 None
None
None
LLP  A 211 ( 2.7A)
None
 1.40A 6fdyU-5x2vA:
undetectable		 6fdyU-5x2vA:
21.76