SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 6 TRP A 164
THR A 140
GLY A  94
TYR A  96
 None
 1.15A 1gtiC-5x32A:
3.1		 1gtiC-5x32A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		5 / 9 GLY A 375
ALA A 374
SER A  54
PHE A  37
LEU A  99
 None
 1.22A 1y7iA-5x32A:
undetectable		 1y7iA-5x32A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		5 / 12 TYR A 141
THR A 140
TYR A 122
ILE A 119
LEU A  85
 None
 1.45A 1z9hA-5x32A:
undetectable		 1z9hA-5x32A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 7 ALA A 186
TYR A 195
TYR A 122
TYR A  96
 None
 0.94A 2ajvH-5x32A:
undetectable
2ajvL-5x32A:
undetectable		 2ajvH-5x32A:
14.55
2ajvL-5x32A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		3 / 3 ARG A 198
VAL A 118
THR A 140
 None
 0.71A 2nmzA-5x32A:
undetectable		 2nmzA-5x32A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 5 LEU A 126
GLN A 191
THR A 190
LEU A  67
 None
 1.01A 3ce6D-5x32A:
undetectable		 3ce6D-5x32A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		3 / 3 ARG A 198
VAL A 118
THR A 140
 None
 0.71A 3k4vD-5x32A:
undetectable		 3k4vD-5x32A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 6 GLU A 181
PHE A 117
ALA A 182
ALA A 116
 None
 1.00A 3ns1C-5x32A:
undetectable		 3ns1C-5x32A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		3 / 3 MET A 179
GLN A 210
TYR A 223
 None
 0.86A 4udcA-5x32A:
undetectable		 4udcA-5x32A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 5 ASP A 158
TRP A 227
GLY A 172
ASN A 176
 None
 1.23A 5x7pB-5x32A:
undetectable		 5x7pB-5x32A:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE
(Marinomonas
mediterranea) 		4 / 8 ILE A 359
THR A 381
GLU A 316
SER A 317
 None
 1.15A 6fbvC-5x32A:
undetectable		 6fbvC-5x32A:
undetectable