SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ASP A 223
ASP A 249
ASP A 227
 None
None
SO4  A 519 (-4.4A)
 0.75A 1eizA-5x3eA:
undetectable		 1eizA-5x3eA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ASP A 223
ASP A 249
ASP A 227
 None
None
SO4  A 519 (-4.4A)
 0.76A 1ej0A-5x3eA:
undetectable		 1ej0A-5x3eA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 7 VAL A  55
SER A  43
ASN A 413
ASP A 408
 None
 1.27A 1hwiC-5x3eA:
undetectable		 1hwiC-5x3eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 7 VAL A  55
SER A  43
ASN A 413
ASP A 408
 None
 1.27A 1hwiD-5x3eA:
undetectable		 1hwiD-5x3eA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 273
ARG A 331
ARG A 274
 None
 1.03A 1l7fA-5x3eA:
undetectable		 1l7fA-5x3eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 273
ARG A 331
ARG A 274
 None
 1.04A 1l7hA-5x3eA:
undetectable		 1l7hA-5x3eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 7 VAL A 211
CYH A 207
CYH A 193
ARG A 136
 None
 1.16A 1t46A-5x3eA:
undetectable		 1t46A-5x3eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 ARG A 242
ASP A 249
ASP A 223
 SO4  A 512 (-4.2A)
None
None
 0.68A 2ejtA-5x3eA:
undetectable		 2ejtA-5x3eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 6 SER A  43
LEU A  44
ASP A 409
ASP A 408
 None
 1.18A 2j2pE-5x3eA:
undetectable
2j2pF-5x3eA:
undetectable		 2j2pE-5x3eA:
20.22
2j2pF-5x3eA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 5 ASP A 325
ARG A 273
TYR A 213
GLU A 270
 None
 1.45A 2x8oA-5x3eA:
undetectable		 2x8oA-5x3eA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 GLU A 128
GLY A 130
THR A 131
 None
 0.56A 3iazA-5x3eA:
undetectable		 3iazA-5x3eA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 5 LEU A 326
GLY A 328
PHE A 419
ASN A 349
 None
 1.24A 3uq6B-5x3eA:
undetectable		 3uq6B-5x3eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 6 SER A 259
ARG A 191
GLY A 130
GLY A 132
 None
 0.99A 4koeA-5x3eA:
undetectable
4koeB-5x3eA:
undetectable
4koeC-5x3eA:
undetectable		 4koeA-5x3eA:
23.96
4koeB-5x3eA:
23.96
4koeC-5x3eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		4 / 7 ASN A 346
TYR A 217
LEU A 383
PHE A 387
 None
 1.16A 4yv5A-5x3eA:
undetectable		 4yv5A-5x3eA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 THR A  41
PRO A 407
ASP A 408
 None
 0.89A 5l8dB-5x3eA:
undetectable		 5l8dB-5x3eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5x3e KINESIN-LIKE PROTEIN
(Caenorhabditis
elegans) 		3 / 3 THR A  41
PRO A 407
ASP A 408
 None
 0.89A 5mwuB-5x3eA:
undetectable		 5mwuB-5x3eA:
21.48