SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		3 / 3 TRP A  27
ALA A  61
VAL A  23
 None
 0.94A 1c4dA-5x3hA:
undetectable
1c4dB-5x3hA:
undetectable		 1c4dA-5x3hA:
4.51
1c4dB-5x3hA:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 12 ALA A 209
GLY A 208
ASN A 168
ALA A  91
ILE A  93
 None
 1.19A 1kxhA-5x3hA:
undetectable		 1kxhA-5x3hA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 11 LEU A  35
VAL A  71
LEU A 165
LEU A  18
LEU A  60
 None
 1.33A 1mx1B-5x3hA:
1.7		 1mx1B-5x3hA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.21A 1nsiA-5x3hA:
undetectable
1nsiB-5x3hA:
undetectable		 1nsiA-5x3hA:
22.06
1nsiB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.22A 1nsiA-5x3hA:
undetectable
1nsiB-5x3hA:
undetectable		 1nsiA-5x3hA:
22.06
1nsiB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.16A 1nsiC-5x3hA:
undetectable
1nsiD-5x3hA:
undetectable		 1nsiC-5x3hA:
22.06
1nsiD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.18A 1nsiC-5x3hA:
undetectable
1nsiD-5x3hA:
undetectable		 1nsiC-5x3hA:
22.06
1nsiD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 SER A 219
LEU A 167
LEU A  31
LEU A  35
 None
 0.91A 2bfpA-5x3hA:
undetectable		 2bfpA-5x3hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 SER A 219
LEU A 167
LEU A  31
LEU A  35
 None
 0.95A 2bfpD-5x3hA:
undetectable		 2bfpD-5x3hA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ASP A 250
PRO A 248
SER A 162
LEU A 228
 None
 0.98A 2hdnE-5x3hA:
undetectable
2hdnF-5x3hA:
undetectable
2hdnH-5x3hA:
undetectable		 2hdnE-5x3hA:
13.42
2hdnF-5x3hA:
21.83
2hdnH-5x3hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 SER A 162
LEU A 228
ASP A 250
PRO A 248
 None
 0.95A 2hdnF-5x3hA:
undetectable
2hdnG-5x3hA:
undetectable
2hdnH-5x3hA:
undetectable		 2hdnF-5x3hA:
21.83
2hdnG-5x3hA:
13.42
2hdnH-5x3hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 12 LEU A 166
ARG A 156
PHE A  63
SER A  64
LEU A 204
 None
 1.28A 2lbdA-5x3hA:
undetectable		 2lbdA-5x3hA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.18A 2nsiA-5x3hA:
undetectable
2nsiB-5x3hA:
undetectable		 2nsiA-5x3hA:
22.06
2nsiB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.17A 2nsiA-5x3hA:
undetectable
2nsiB-5x3hA:
undetectable		 2nsiA-5x3hA:
22.06
2nsiB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.18A 2nsiC-5x3hA:
undetectable
2nsiD-5x3hA:
undetectable		 2nsiC-5x3hA:
22.06
2nsiD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.18A 2nsiC-5x3hA:
undetectable
2nsiD-5x3hA:
undetectable		 2nsiC-5x3hA:
22.06
2nsiD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		3 / 3 PHE A 207
PHE A  92
PHE A 159
 None
 0.85A 2od9A-5x3hA:
2.0		 2od9A-5x3hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 5 LEU A 148
ALA A 123
ILE A 120
LYS A 145
 None
 1.11A 2othA-5x3hA:
undetectable		 2othA-5x3hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		3 / 3 PHE A 207
PHE A  92
PHE A 159
 None
 0.85A 2qqgA-5x3hA:
2.0		 2qqgA-5x3hA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.17A 3e7gA-5x3hA:
undetectable
3e7gB-5x3hA:
undetectable		 3e7gA-5x3hA:
22.06
3e7gB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.17A 3e7gA-5x3hA:
undetectable
3e7gB-5x3hA:
undetectable		 3e7gA-5x3hA:
22.06
3e7gB-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.20A 3e7gC-5x3hA:
undetectable
3e7gD-5x3hA:
undetectable		 3e7gC-5x3hA:
22.06
3e7gD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.18A 3e7gC-5x3hA:
undetectable
3e7gD-5x3hA:
undetectable		 3e7gC-5x3hA:
22.06
3e7gD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		3 / 3 ALA A 113
ARG A 117
LYS A 121
 None
 1.02A 3kp5B-5x3hA:
undetectable		 3kp5B-5x3hA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.21A 4cx7A-5x3hA:
undetectable
4cx7B-5x3hA:
undetectable		 4cx7A-5x3hA:
22.06
4cx7B-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.17A 4cx7A-5x3hA:
undetectable
4cx7B-5x3hA:
undetectable		 4cx7A-5x3hA:
22.06
4cx7B-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 ILE A  30
TRP A  27
PHE A  63
GLU A  28
 None
 1.12A 4cx7C-5x3hA:
undetectable
4cx7D-5x3hA:
undetectable		 4cx7C-5x3hA:
22.06
4cx7D-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.16A 4cx7C-5x3hA:
undetectable
4cx7D-5x3hA:
undetectable		 4cx7C-5x3hA:
22.06
4cx7D-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 4 LEU A 148
ALA A 123
ILE A 120
LYS A 145
 None
 1.10A 4eixA-5x3hA:
undetectable		 4eixA-5x3hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 12 LEU A  75
PHE A 159
ASP A 250
MET A 249
GLY A 247
 None
 1.39A 4j7xA-5x3hA:
undetectable		 4j7xA-5x3hA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 12 LEU A  75
PHE A 159
ASP A 250
MET A 249
GLY A 247
 None
 1.42A 4j7xF-5x3hA:
undetectable		 4j7xF-5x3hA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 TRP A  27
PHE A  63
GLU A  28
ILE A  30
 None
 1.21A 4nosC-5x3hA:
undetectable
4nosD-5x3hA:
undetectable		 4nosC-5x3hA:
22.06
4nosD-5x3hA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		5 / 11 LEU A 228
PHE A  92
GLY A  77
ILE A 205
PRO A 231
 None
 1.34A 5hjiA-5x3hA:
undetectable		 5hjiA-5x3hA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		3 / 3 LEU A  14
LEU A  31
TRP A  27
 None
 0.91A 5nwuA-5x3hA:
undetectable		 5nwuA-5x3hA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 6 PHE A  63
TRP A  27
SER A  64
GLY A  22
 None
 1.13A 5o4yF-5x3hA:
undetectable		 5o4yF-5x3hA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 8 GLY A 222
GLY A 201
LEU A 223
GLU A 195
 None
 0.88A 6mdqA-5x3hA:
undetectable		 6mdqA-5x3hA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5x3h URACIL-DNA
GLYCOSYLASE
(Nitratifractor
salsuginis) 		4 / 7 ILE A 205
LEU A  75
MET A 249
LEU A 251
 None
 0.91A 6nmfA-5x3hA:
undetectable
6nmfJ-5x3hA:
undetectable		 6nmfA-5x3hA:
19.53
6nmfJ-5x3hA:
10.27