SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 VAL A  35
VAL A  90
TRP A  88
 None
 0.77A 1av2A-5x3jA:
undetectable
1av2B-5x3jA:
undetectable		 1av2A-5x3jA:
undetectable
1av2B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ILE A 663
MET A 572
LEU A 612
PHE A 722
LEU A 718
 None
 1.21A 1dtlA-5x3jA:
undetectable		 1dtlA-5x3jA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 ARG A 270
ASP A 256
ASN A 215
 None
 0.87A 1nbhA-5x3jA:
undetectable		 1nbhA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 ARG A 270
ASP A 256
ASN A 215
 None
 0.87A 1nbhD-5x3jA:
undetectable		 1nbhD-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 ASP A 164
PHE A 639
ASN A 215
 None
 0.83A 1sg9B-5x3jA:
undetectable		 1sg9B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 VAL A  35
VAL A  90
TRP A  88
 None
 0.76A 1w5uA-5x3jA:
undetectable
1w5uB-5x3jA:
undetectable		 1w5uA-5x3jA:
undetectable
1w5uB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 11 LEU A 158
LEU A 236
VAL A 142
GLY A 154
ARG A 153
 None
None
None
None
SO4  A 806 (-3.3A)
 1.48A 1y4lB-5x3jA:
undetectable		 1y4lB-5x3jA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 TYR A 463
GLY A 502
PHE A 503
SER A 506
 None
 0.91A 2a3cA-5x3jA:
1.9		 2a3cA-5x3jA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 TYR A 463
GLY A 502
PHE A 503
SER A 506
 None
 0.90A 2a3cB-5x3jA:
7.3		 2a3cB-5x3jA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 8 TYR A 191
GLU A 314
HIS A 575
GLY A 285
 GLC  A 819 ( 4.3A)
GLC  A 822 ( 2.6A)
GLC  A 822 ( 4.0A)
None
 1.12A 2ha4A-5x3jA:
undetectable		 2ha4A-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 7 TYR A 191
GLU A 314
HIS A 575
GLY A 285
 GLC  A 819 ( 4.3A)
GLC  A 822 ( 2.6A)
GLC  A 822 ( 4.0A)
None
 1.10A 2ha4B-5x3jA:
undetectable		 2ha4B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 TRP A 591
PRO A 590
LEU A 546
GLY A 285
 GOL  A 814 (-4.4A)
None
None
None
 1.13A 2hs2B-5x3jA:
undetectable		 2hs2B-5x3jA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 VAL A  90
TRP A  88
VAL A  35
 None
 0.77A 2izqC-5x3jA:
undetectable
2izqD-5x3jA:
undetectable		 2izqC-5x3jA:
undetectable
2izqD-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 GLY A 168
GLY A 538
PHE A 640
PHE A 639
 None
 0.95A 2qx6A-5x3jA:
undetectable
2qx6B-5x3jA:
undetectable		 2qx6A-5x3jA:
15.93
2qx6B-5x3jA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 TRP A 372
ARG A 500
TRP A 513
HIS A 575
 GLC  A 822 ( 4.3A)
GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 4.0A)
 1.42A 3deuA-5x3jA:
undetectable		 3deuA-5x3jA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 GLY A 453
GLU A 454
GLU A 189
GLU A 171
 None
None
GLC  A 819 ( 2.8A)
None
 0.99A 3fpjA-5x3jA:
undetectable		 3fpjA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 PRO A 590
HIS A 301
LEU A 281
ALA A 563
 None
 1.27A 3gv1A-5x3jA:
undetectable
3gv1C-5x3jA:
undetectable		 3gv1A-5x3jA:
undetectable
3gv1C-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 LEU A 281
ALA A 563
PRO A 590
HIS A 301
 None
 1.24A 3gv1A-5x3jA:
undetectable
3gv1B-5x3jA:
undetectable		 3gv1A-5x3jA:
undetectable
3gv1B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 LEU A 274
TYR A 541
ILE A 511
PHE A 279
ALA A 310
 None
 0.99A 3gwwA-5x3jA:
undetectable		 3gwwA-5x3jA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 9 THR A 529
ALA A 530
LEU A 532
ALA A 534
SER A 536
 None
 1.13A 3kp6B-5x3jA:
undetectable		 3kp6B-5x3jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.59A 3phaA-5x3jA:
31.4		 3phaA-5x3jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.55A 3phaC-5x3jA:
30.3		 3phaC-5x3jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.56A 3pocA-5x3jA:
30.4		 3pocA-5x3jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.57A 3pocB-5x3jA:
31.6		 3pocB-5x3jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 PHE A 568
GLN A 654
PHE A 722
 None
 0.84A 3rv5A-5x3jA:
undetectable		 3rv5A-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 LEU A 718
GLY A 689
CYH A 710
ILE A 684
LEU A 612
 None
 1.07A 3uj7B-5x3jA:
undetectable		 3uj7B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 ASP A 645
ASP A 177
ASN A 650
GLU A 647
 None
 1.31A 3vywA-5x3jA:
undetectable		 3vywA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 ASP A 465
GLU A 471
GLY A 472
ASP A 422
 None
 0.83A 3w9tD-5x3jA:
undetectable		 3w9tD-5x3jA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 TYR A 191
ARG A 500
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 4.3A)
GLC  A 819 ( 2.9A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.77A 4b9zA-5x3jA:
29.4		 4b9zA-5x3jA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 TRP A 432
TRP A 431
THR A 428
 None
 1.33A 4bboB-5x3jA:
undetectable		 4bboB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 ARG A 179
TRP A 649
GLY A 211
 None
 1.01A 4e7cA-5x3jA:
2.5		 4e7cA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 7 GLY A 452
GLY A 453
TYR A 480
GLU A 189
 None
None
None
GLC  A 819 ( 2.8A)
 0.92A 4fgkB-5x3jA:
undetectable		 4fgkB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 10 GLY A  70
GLY A  69
GLU A  71
VAL A 196
GLN A 194
 None
 1.12A 4fgkA-5x3jA:
undetectable
4fgkB-5x3jA:
undetectable		 4fgkA-5x3jA:
undetectable
4fgkB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 7 ASP A 465
ASP A 422
HIS A 479
SER A 424
 None
None
GOL  A 816 (-3.8A)
None
 1.20A 4k7gB-5x3jA:
0.4		 4k7gB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 7 THR A 589
TRP A 591
TRP A 288
LEU A 585
 None
GOL  A 814 (-4.4A)
None
GOL  A 814 (-4.8A)
 0.85A 4nsbA-5x3jA:
2.8		 4nsbA-5x3jA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.85A 4w5oA-5x3jA:
undetectable		 4w5oA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.85A 4z4cA-5x3jA:
undetectable		 4z4cA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.85A 4z4dA-5x3jA:
undetectable		 4z4dA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.86A 4z4eA-5x3jA:
undetectable		 4z4eA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 VAL A 666
ALA A 564
PHE A 524
 None
 0.88A 4z4iA-5x3jA:
1.2		 4z4iA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 4 LEU A 274
TYR A 619
PRO A 570
ILE A 571
 None
 1.17A 5esgA-5x3jA:
undetectable		 5esgA-5x3jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 VAL A 666
ALA A 564
PHE A 524
 None
 0.86A 5js1A-5x3jA:
undetectable		 5js1A-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ASP A 545
LEU A 560
ALA A 563
SER A 566
PHE A 606
 None
 1.16A 5nd7B-5x3jA:
undetectable		 5nd7B-5x3jA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 6 PRO A 665
VAL A 666
ALA A 564
PHE A 524
 None
 0.82A 5t7bA-5x3jA:
undetectable		 5t7bA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 10 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.74A 5x7pA-5x3jA:
21.9		 5x7pA-5x3jA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		4 / 5 ALA A 680
SER A 694
GLY A 695
TYR A 677
 None
 1.11A 5yodB-5x3jA:
undetectable		 5yodB-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 GLN A 373
VAL A 312
VAL A 369
SER A 499
GLU A 454
 None
 1.37A 6bzoC-5x3jA:
undetectable		 6bzoC-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.54A 6c9zA-5x3jA:
30.2		 6c9zA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.57A 6ca1A-5x3jA:
30.5		 6ca1A-5x3jA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.59A 6ca1B-5x3jA:
30.4		 6ca1B-5x3jA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.60A 6ca3A-5x3jA:
31.4		 6ca3A-5x3jA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 12 ARG A 500
TRP A 513
ASP A 516
PHE A 549
HIS A 575
 GLC  A 819 ( 2.9A)
GLC  A 822 ( 4.6A)
GLC  A 822 ( 2.8A)
GLC  A 822 ( 4.8A)
GLC  A 822 ( 4.0A)
 0.57A 6ca3B-5x3jA:
30.4		 6ca3B-5x3jA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		3 / 3 ALA A  14
PHE A 188
GLN A 190
 None
 0.61A 6eceA-5x3jA:
undetectable		 6eceA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5x3j GLYCOSIDE HYDROLASE
FAMILY 31
(Kribbella
flavida) 		5 / 11 TRP A 228
ASP A 184
TYR A  13
GLY A 412
ALA A 418
 None
 1.36A 6hu9A-5x3jA:
undetectable
6hu9E-5x3jA:
undetectable
6hu9I-5x3jA:
undetectable		 6hu9A-5x3jA:
undetectable
6hu9E-5x3jA:
undetectable
6hu9I-5x3jA:
undetectable