SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x3r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIQ_A_STIA1001_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	5x3r	LUXR FAMILY TRANSCRIPTIONAL REGULATOR (Vibrio vulnificus)	4 / 5	LEU A 103 VAL A 64 LEU A 63 ARG A 36	None	1.12A	2oiqA-5x3rA: undetectable	2oiqA-5x3rA: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZXW_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5x3r	LUXR FAMILY TRANSCRIPTIONAL REGULATOR (Vibrio vulnificus)	4 / 6	GLN A 141 PHE A 144 LEU A 79 PHE A 75	None None None 7Y3 A 601 (-4.3A)	0.98A	2zxwP-5x3rA: undetectable 2zxwW-5x3rA: undetectable	2zxwP-5x3rA: undetectable 2zxwW-5x3rA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABL_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5x3r	LUXR FAMILY TRANSCRIPTIONAL REGULATOR (Vibrio vulnificus)	4 / 5	GLN A 141 PHE A 144 LEU A 79 PHE A 75	None None None 7Y3 A 601 (-4.3A)	0.87A	3ablC-5x3rA: undetectable 3ablJ-5x3rA: undetectable	3ablC-5x3rA: undetectable 3ablJ-5x3rA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5x3r	LUXR FAMILY TRANSCRIPTIONAL REGULATOR (Vibrio vulnificus)	4 / 6	GLN A 141 PHE A 144 LEU A 79 PHE A 78	None	1.19A	6nmpC-5x3rA: undetectable 6nmpJ-5x3rA: undetectable	6nmpC-5x3rA: undetectable 6nmpJ-5x3rA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OIQ_A_STIA1001_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","5x3r","LUXR FAMILY TRANSCRIPTIONAL REGULATOR","Vibrio vulnificus",4,"LEU A 103;VAL A  64;LEU A  63;ARG A  36","None","1.12A","2oiqA-5x3rA:undetectable","2oiqA-5x3rA:15.02"],["2ZXW_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5x3r","LUXR FAMILY TRANSCRIPTIONAL REGULATOR","Vibrio vulnificus",4,"GLN A 141;PHE A 144;LEU A  79;PHE A  75","None;None;None;7Y3 A 601 (-4.3A)","0.98A","2zxwP-5x3rA:undetectable;2zxwW-5x3rA:undetectable","2zxwP-5x3rA:undetectable;2zxwW-5x3rA:undetectable"],["3ABL_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","5x3r","LUXR FAMILY TRANSCRIPTIONAL REGULATOR","Vibrio vulnificus",4,"GLN A 141;PHE A 144;LEU A  79;PHE A  75","None;None;None;7Y3 A 601 (-4.3A)","0.87A","3ablC-5x3rA:undetectable;3ablJ-5x3rA:undetectable","3ablC-5x3rA:undetectable;3ablJ-5x3rA:undetectable"],["6NMP_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","5x3r","LUXR FAMILY TRANSCRIPTIONAL REGULATOR","Vibrio vulnificus",4,"GLN A 141;PHE A 144;LEU A  79;PHE A  78","None","1.19A","6nmpC-5x3rA:undetectable;6nmpJ-5x3rA:undetectable","6nmpC-5x3rA:undetectable;6nmpJ-5x3rA:undetectable"]]