SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 12 LEU A  65
PHE A  68
LEU B  46
ILE B  95
VAL B  59
 None
 1.37A 1hrkB-5x3tA:
undetectable		 1hrkB-5x3tA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 ILE B  84
ARG B 106
ILE B   2
PHE B 120
 None
 1.08A 2q6hA-5x3tB:
undetectable		 2q6hA-5x3tB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 6 ILE B  84
ARG B 106
ILE B   2
PHE B 120
 None
 1.09A 2q72A-5x3tB:
undetectable		 2q72A-5x3tB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 ILE B  84
ARG B 106
ILE B   2
PHE B 120
 None
 1.07A 2qb4A-5x3tB:
undetectable		 2qb4A-5x3tB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  48
ILE B   3
LEU B 113
LEU B  43
LEU B  63
 None
 1.15A 3cs8A-5x3tA:
undetectable		 3cs8A-5x3tA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 TYR B  88
VAL B  39
VAL B 102
ILE B  95
 None
 1.29A 3ms9B-5x3tB:
undetectable		 3ms9B-5x3tB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		5 / 12 LEU A  65
PHE A  68
LEU B  46
ILE B  95
VAL B  59
 None
 1.35A 3w1wB-5x3tA:
undetectable		 3w1wB-5x3tA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 5 GLU B  56
THR B  49
TYR B  45
ASP B  44
 None
 1.17A 3zs3A-5x3tB:
undetectable		 3zs3A-5x3tB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5x3t ANTITOXIN VAPB26
RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		3 / 4 ARG A  47
GLY A  48
GLU B  62
 None
 0.54A 4z2dB-5x3tA:
undetectable
4z2dC-5x3tA:
undetectable		 4z2dB-5x3tA:
10.00
4z2dC-5x3tA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 PHE B 120
VAL B 133
SER B   6
THR B 114
 None
 0.98A 5vkqA-5x3tB:
undetectable
5vkqD-5x3tB:
undetectable		 5vkqA-5x3tB:
6.60
5vkqD-5x3tB:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 SER B   6
THR B 114
PHE B 120
VAL B 133
 None
 0.99A 5vkqA-5x3tB:
undetectable
5vkqB-5x3tB:
undetectable		 5vkqA-5x3tB:
6.60
5vkqB-5x3tB:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 8 SER B   6
THR B 114
PHE B 120
VAL B 133
 None
 1.00A 5vkqB-5x3tB:
undetectable
5vkqC-5x3tB:
undetectable		 5vkqB-5x3tB:
6.60
5vkqC-5x3tB:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5x3t RIBONUCLEASE VAPC26
(Mycobacterium
tuberculosis) 		4 / 7 SER B   6
THR B 114
PHE B 120
VAL B 133
 None
 1.00A 5vkqC-5x3tB:
undetectable
5vkqD-5x3tB:
undetectable		 5vkqC-5x3tB:
6.60
5vkqD-5x3tB:
6.60