SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 6 PHE A 195
VAL A 210
ALA A 224
LEU A 228
None
0.75A 1e7bB-5x41A:
undetectable
1e7bB-5x41A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 THR M 197
GLY M 194
LEU M  93
VAL M  92
LEU M  55
None
1.20A 1r30A-5x41M:
undetectable
1r30A-5x41M:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 THR M 197
GLY M 194
LEU M  93
VAL M  92
LEU M  55
None
1.20A 1r30B-5x41M:
undetectable
1r30B-5x41M:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 5 VAL M  90
GLY M  89
VAL M  87
TRP M 121
None
1.35A 1tkqB-5x41M:
undetectable
1tkqB-5x41M:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.89A 1v54A-5x41M:
1.7
1v54J-5x41M:
undetectable
1v54A-5x41M:
19.61
1v54J-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 ALA M 151
TYR M 153
GLY M 148
LEU M 147
PHE M 146
None
1.27A 1vpoH-5x41M:
undetectable
1vpoL-5x41M:
undetectable
1vpoH-5x41M:
22.76
1vpoL-5x41M:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.85A 2dyrA-5x41M:
1.8
2dyrJ-5x41M:
undetectable
2dyrA-5x41M:
19.61
2dyrJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.86A 2dysA-5x41M:
undetectable
2dysJ-5x41M:
undetectable
2dysA-5x41M:
19.61
2dysJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.82A 2dysN-5x41M:
undetectable
2dysW-5x41M:
undetectable
2dysN-5x41M:
19.61
2dysW-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.92A 2eijA-5x41M:
undetectable
2eijJ-5x41M:
undetectable
2eijA-5x41M:
19.61
2eijJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.91A 2eilA-5x41M:
2.1
2eilJ-5x41M:
undetectable
2eilA-5x41M:
19.61
2eilJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
5 / 9 GLY A  53
LEU A  55
TYR A  12
THR A  54
LEU A  21
None
1.29A 2npnA-5x41A:
undetectable
2npnA-5x41A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 5 VAL M 154
THR M 155
VAL M 118
GLY M 119
None
0.60A 2p2fA-5x41M:
undetectable
2p2fA-5x41M:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 4 VAL M 154
THR M 155
VAL M 118
GLY M 119
None
0.66A 2p2fB-5x41M:
undetectable
2p2fB-5x41M:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 6 LEU A 183
LEU A 180
ILE A 151
ARG A 148
None
0.75A 2rlfA-5x41A:
undetectable
2rlfB-5x41A:
undetectable
2rlfA-5x41A:
10.19
2rlfB-5x41A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 6 LEU A 183
LEU A 180
ILE A 151
ARG A 148
None
0.88A 2rlfC-5x41A:
undetectable
2rlfD-5x41A:
undetectable
2rlfC-5x41A:
10.19
2rlfD-5x41A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 11 PRO M 120
THR M  73
GLY M  74
THR M 197
VAL M 141
None
1.34A 2uvnB-5x41M:
1.0
2uvnB-5x41M:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.88A 2zxwA-5x41M:
1.6
2zxwJ-5x41M:
undetectable
2zxwA-5x41M:
19.61
2zxwJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.84A 3abmA-5x41M:
1.7
3abmJ-5x41M:
undetectable
3abmA-5x41M:
19.61
3abmJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.86A 3asnA-5x41M:
undetectable
3asnJ-5x41M:
undetectable
3asnA-5x41M:
19.61
3asnJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.85A 3asoA-5x41M:
undetectable
3asoJ-5x41M:
undetectable
3asoA-5x41M:
19.61
3asoJ-5x41M:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 LEU M 108
ALA M 112
ALA M  20
PRO M  22
VAL M  25
None
1.12A 3cwkA-5x41M:
undetectable
3cwkA-5x41M:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 9 VAL M  35
ILE M  34
ARG M  38
ILE M  31
GLY M  81
None
1.11A 4kukA-5x41M:
undetectable
4kukA-5x41M:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
5 / 9 ALA A 207
LEU A 183
PHE A 195
THR A 197
LEU A  37
None
1.42A 4ltwA-5x41A:
undetectable
4ltwA-5x41A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 4 LEU A  37
SER A 196
LEU A 202
LEU A 239
None
0.86A 4n09A-5x41A:
undetectable
4n09A-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 5 LEU A  37
SER A 196
LEU A 202
LEU A 239
None
0.86A 4n09B-5x41A:
undetectable
4n09B-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
4 / 5 LEU A  37
SER A 196
LEU A 202
LEU A 239
None
0.84A 4n09D-5x41A:
undetectable
4n09D-5x41A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 LEU M  55
PHE M  51
GLY M  74
VAL M 200
VAL M 201
None
1.04A 4nkvA-5x41M:
undetectable
4nkvA-5x41M:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 LEU M  55
PHE M  51
GLY M  74
VAL M 200
VAL M 201
None
1.04A 4nkvC-5x41M:
1.3
4nkvC-5x41M:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 LEU M  55
PHE M  51
GLY M  74
VAL M 200
VAL M 201
None
1.03A 4nkvD-5x41M:
undetectable
4nkvD-5x41M:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 10 SER M 157
THR M 152
SER M 114
GLU M 193
ASP M 149
None
1.47A 4qb9A-5x41M:
undetectable
4qb9A-5x41M:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 10 SER M 157
THR M 152
SER M 114
GLU M 193
ASP M 149
None
1.33A 4qb9C-5x41M:
undetectable
4qb9C-5x41M:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 SER M 157
THR M 152
SER M 114
GLU M 193
ASP M 149
None
1.47A 4qb9E-5x41M:
undetectable
4qb9E-5x41M:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
3 / 3 GLY M  81
PRO M  82
ALA M 123
None
0.52A 4qn9B-5x41M:
undetectable
4qn9B-5x41M:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 8 ALA M 116
HIS M   2
ASN M 111
THR M  73
None
1.08A 5db5A-5x41M:
undetectable
5db5B-5x41M:
undetectable
5db5A-5x41M:
22.52
5db5B-5x41M:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
5 / 12 ALA A 224
ASP A 199
THR A 168
SER A 196
SER A  33
None
1.34A 5hfjB-5x41A:
undetectable
5hfjB-5x41A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5x41 COBALT ABC
TRANSPORTER
ATP-BINDING PROTEIN

(Rhodobacter
capsulatus)
5 / 12 ASP A 208
ALA A 224
ASP A 199
THR A 168
SER A  33
None
1.19A 5hfjH-5x41A:
undetectable
5hfjH-5x41A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
5 / 12 TYR M 127
GLY M  76
VAL M  84
VAL M  79
LEU M 204
None
1.07A 5ubbA-5x41M:
undetectable
5ubbA-5x41M:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus)
4 / 6 LEU M 176
TYR M 153
THR M 155
LEU M 158
None
0.88A 5x1fA-5x41M:
undetectable
5x1fJ-5x41M:
undetectable
5x1fA-5x41M:
19.61
5x1fJ-5x41M:
13.49