SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 6 GLN A  90
CYH A  16
ASP A  34
HIS A  18
 None
 1.15A 1ekjG-5x45A:
undetectable
1ekjH-5x45A:
undetectable		 1ekjG-5x45A:
undetectable
1ekjH-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		3 / 3 CYH A  53
ARG A 133
CYH A 111
 ZN  A 201 (-2.6A)
None
ZN  A 201 (-2.5A)
 0.96A 1p9gA-5x45A:
undetectable		 1p9gA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 7 GLN A  90
ILE A 119
TYR A  84
CYH A 100
 None
 1.37A 2xz5D-5x45A:
undetectable
2xz5E-5x45A:
undetectable		 2xz5D-5x45A:
undetectable
2xz5E-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 5 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.25A 2yldA-5x45A:
undetectable		 2yldA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 5 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.27A 2ylgA-5x45A:
undetectable		 2ylgA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 7 LEU A  28
ASP A  38
ALA A  12
TYR A  14
 None
 1.07A 3rodD-5x45A:
undetectable		 3rodD-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		5 / 12 TYR A 135
LEU A  28
LEU A  93
ALA A 121
ALA A 128
 None
 1.11A 3vw7A-5x45A:
undetectable		 3vw7A-5x45A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 5 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.26A 3zwiA-5x45A:
undetectable		 3zwiA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 4 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.25A 4cipA-5x45A:
undetectable		 4cipA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 6 ALA A  30
ARG A 133
GLY A 117
THR A  54
 None
 0.96A 5btgA-5x45A:
undetectable
5btgB-5x45A:
undetectable
5btgC-5x45A:
undetectable		 5btgA-5x45A:
10.75
5btgB-5x45A:
19.47
5btgC-5x45A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 5 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.26A 5jliA-5x45A:
undetectable		 5jliA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 4 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.25A 5jslA-5x45A:
undetectable		 5jslA-5x45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5x45 PROTEASE 2A
(Rhinovirus
C) 		4 / 5 ALA A 121
GLY A 106
CYH A  16
HIS A  18
 None
 1.26A 5jt4A-5x45A:
undetectable		 5jt4A-5x45A:
undetectable