SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 12 LEU A 116
LEU A 107
THR A  58
ILE A 144
LEU A 155
 None
 0.94A 1tw4B-5x4bA:
undetectable		 1tw4B-5x4bA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 10 LEU A 156
GLY A 153
LEU A 155
ILE A 144
ILE A  23
 None
K  A 202 (-3.7A)
None
None
None
 0.87A 2f8dA-5x4bA:
undetectable		 2f8dA-5x4bA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 10 LEU A 156
GLY A 153
LEU A 155
ILE A 144
ILE A  23
 None
K  A 202 (-3.7A)
None
None
None
 0.88A 2f8dB-5x4bA:
undetectable		 2f8dB-5x4bA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 11 PHE A  88
THR A  97
LEU A 136
VAL A  90
THR A  58
 None
 1.12A 3n0hA-5x4bA:
undetectable		 3n0hA-5x4bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 12 PHE A  88
THR A  97
LEU A 136
VAL A  90
THR A  58
 None
 1.11A 3s3vA-5x4bA:
undetectable		 3s3vA-5x4bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5x4b GTPASE DER
(Bacillus
subtilis) 		5 / 10 ILE A  42
GLU A  26
SER A  45
ILE A  56
GLU A  82
 None
 1.41A 3u6tA-5x4bA:
undetectable		 3u6tA-5x4bA:
19.11