SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		3 / 3 ASP A  29
ARG A  83
ILE A  32
 None
 0.70A 1a4gB-5x4lA:
undetectable		 1a4gB-5x4lA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 SER A  37
CYH A 174
ILE A 114
THR A 180
 None
 0.97A 3bpxA-5x4lA:
undetectable
3bpxB-5x4lA:
undetectable		 3bpxA-5x4lA:
21.47
3bpxB-5x4lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ASP A 150
VAL A 116
ILE A 175
THR A 168
VAL A 165
 None
 1.14A 3gguA-5x4lA:
2.9		 3gguA-5x4lA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		5 / 12 ILE A 100
ALA A  67
LEU A  59
VAL A  57
LEU A  72
 None
 1.00A 3ozuA-5x4lA:
undetectable		 3ozuA-5x4lA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 8 VAL A  39
ARG A  89
VAL A  94
ILE A 100
 None
 1.06A 3remA-5x4lA:
undetectable		 3remA-5x4lA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens) 		4 / 4 LYS A  62
ARG A  93
GLY A  61
ASP A  98
 None
 1.31A 4ryaA-5x4lA:
undetectable		 4ryaA-5x4lA:
16.47