SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 9 PHE A 116
LEU A 284
PHE A 112
PHE A 183
LEU A 265
None
1.26A 1wrkA-5x4rA:
undetectable
1wrkB-5x4rA:
undetectable
1wrkA-5x4rA:
13.15
1wrkB-5x4rA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 ALA A 336
PHE A 323
ILE A  48
ASP A  54
None
1.10A 1yc2D-5x4rA:
undetectable
1yc2D-5x4rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 ILE A 250
LEU A 273
TYR A 144
THR A 178
NAG  A 502 ( 4.3A)
None
None
None
1.03A 2zxwN-5x4rA:
undetectable
2zxwW-5x4rA:
undetectable
2zxwN-5x4rA:
19.89
2zxwW-5x4rA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 ILE A 250
LEU A 273
TYR A 144
THR A 178
NAG  A 502 ( 4.3A)
None
None
None
1.04A 3ag2N-5x4rA:
undetectable
3ag2W-5x4rA:
undetectable
3ag2N-5x4rA:
19.89
3ag2W-5x4rA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 ALA A  53
ASP A  54
ILE A  48
ILE A 337
ILE A  56
None
0.98A 3ekxB-5x4rA:
undetectable
3ekxB-5x4rA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 ALA A  53
ASP A  54
ILE A  48
ILE A 337
ILE A  56
None
0.90A 3ndxB-5x4rA:
undetectable
3ndxB-5x4rA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 4 TYR A 231
THR A 202
VAL A 102
ILE A  31
None
1.46A 4jx1F-5x4rA:
undetectable
4jx1F-5x4rA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 6 SER A 328
GLY A  55
ASP A  54
GLY A 276
None
1.04A 4koeA-5x4rA:
undetectable
4koeB-5x4rA:
undetectable
4koeC-5x4rA:
undetectable
4koeA-5x4rA:
21.64
4koeB-5x4rA:
21.64
4koeC-5x4rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 6 ILE A 250
LEU A 273
TYR A 144
THR A 178
NAG  A 502 ( 4.3A)
None
None
None
1.05A 5b1aN-5x4rA:
undetectable
5b1aW-5x4rA:
undetectable
5b1aN-5x4rA:
19.89
5b1aW-5x4rA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 ARG A 141
GLU A 249
GLY A 121
TRP A 310
None
0.80A 5kf8A-5x4rA:
undetectable
5kf8A-5x4rA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VYH_A_FOLA409_0
(S PROTEIN)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
10 / 10 TRP A  44
PRO A  45
ARG A  46
PRO A  47
HIS A  81
ALA A 123
GLY A 128
THR A 129
ILE A 140
ALA A 312
None
0.39A 5vyhA-5x4rA:
54.9
5vyhA-5x4rA:
98.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5x4r S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 HIS A 298
PHE A 228
PHE A 183
LEU A 187
None
1.11A 5y2tB-5x4rA:
undetectable
5y2tB-5x4rA:
undetectable