SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXZ_A_0LIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 9	LEU A 60 TYR A 88 ILE A 81 ARG A 99 LEU A 209	None	1.46A	3oxzA-5x4sA: undetectable	3oxzA-5x4sA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Q_A_9PLA501_1 (CYTOCHROME P450 2A6)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 10	PHE A 103 PHE A 83 ASN A 189 PHE A 187 ILE A 125	None	1.49A	3t3qA-5x4sA: undetectable	3t3qA-5x4sA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Q_B_9PLB501_1 (CYTOCHROME P450 2A6)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 10	PHE A 103 PHE A 83 ASN A 189 PHE A 187 ILE A 125	None	1.44A	3t3qB-5x4sA: undetectable	3t3qB-5x4sA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Q_C_9PLC501_1 (CYTOCHROME P450 2A6)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 10	PHE A 103 PHE A 83 ASN A 189 PHE A 187 ILE A 125	None	1.45A	3t3qC-5x4sA: undetectable	3t3qC-5x4sA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3Q_D_9PLD501_1 (CYTOCHROME P450 2A6)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 10	PHE A 103 PHE A 83 ASN A 189 PHE A 187 ILE A 125	None	1.45A	3t3qD-5x4sA: undetectable	3t3qD-5x4sA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_B_AERB601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	4 / 5	TYR A 200 ARG A 183 GLU A 184 VAL A 66	None	1.44A	4nkvB-5x4sA: undetectable	4nkvB-5x4sA: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AMK_A_EF2A151_1 (CEREBLON ISOFORM 4)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	4 / 8	ASN A 78 PRO A 79 PHE A 76 PHE A 69	None	1.34A	5amkA-5x4sA: undetectable	5amkA-5x4sA: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VOO_D_C2FD3001_0 (5-METHYLTETRAHYDROFO LATE HOMOCYSTEINE S-METHYLTRANSFERASE)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 12	GLY A 39 LEU A 194 GLY A 86 PHE A 59 ILE A 87	None	1.13A	5vooD-5x4sA: undetectable	5vooD-5x4sA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MHT_D_SAMD328_0 (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI)	5x4s	SPIKE GLYCOPROTEIN (Severe acute respiratory syndrome-related coronavirus)	5 / 12	PHE A 253 GLY A 255 ASP A 77 ASN A 65 SER A 64	None	1.02A	6mhtA-5x4sA: undetectable	6mhtA-5x4sA: 22.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OXZ_A_0LIA1_2","TYROSINE-PROTEIN KINASE ABL1","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"LEU A  60;TYR A  88;ILE A  81;ARG A  99;LEU A 209","None","1.46A","3oxzA-5x4sA:undetectable","3oxzA-5x4sA:18.79"],["3T3Q_A_9PLA501_1","CYTOCHROME P450 2A6","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"PHE A 103;PHE A  83;ASN A 189;PHE A 187;ILE A 125","None","1.49A","3t3qA-5x4sA:undetectable","3t3qA-5x4sA:19.33"],["3T3Q_B_9PLB501_1","CYTOCHROME P450 2A6","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"PHE A 103;PHE A  83;ASN A 189;PHE A 187;ILE A 125","None","1.44A","3t3qB-5x4sA:undetectable","3t3qB-5x4sA:19.33"],["3T3Q_C_9PLC501_1","CYTOCHROME P450 2A6","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"PHE A 103;PHE A  83;ASN A 189;PHE A 187;ILE A 125","None","1.45A","3t3qC-5x4sA:undetectable","3t3qC-5x4sA:19.33"],["3T3Q_D_9PLD501_1","CYTOCHROME P450 2A6","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"PHE A 103;PHE A  83;ASN A 189;PHE A 187;ILE A 125","None","1.45A","3t3qD-5x4sA:undetectable","3t3qD-5x4sA:19.33"],["4NKV_B_AERB601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",4,"TYR A 200;ARG A 183;GLU A 184;VAL A  66","None","1.44A","4nkvB-5x4sA:undetectable","4nkvB-5x4sA:21.50"],["5AMK_A_EF2A151_1","CEREBLON ISOFORM 4","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",4,"ASN A  78;PRO A  79;PHE A  76;PHE A  69","None","1.34A","5amkA-5x4sA:undetectable","5amkA-5x4sA:18.64"],["5VOO_D_C2FD3001_0","5-METHYLTETRAHYDROFOLATE HOMOCYSTEINE S-METHYLTRANSFERASE","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"GLY A  39;LEU A 194;GLY A  86;PHE A  59;ILE A  87","None","1.13A","5vooD-5x4sA:undetectable","5vooD-5x4sA:19.82"],["6MHT_D_SAMD328_0","CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI","5x4s","SPIKE GLYCOPROTEIN","Severe acute respiratory syndrome-related coronavirus",5,"PHE A 253;GLY A 255;ASP A  77;ASN A  65;SER A  64","None","1.02A","6mhtA-5x4sA:undetectable","6mhtA-5x4sA:22.35"]]