SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 7 THR A 330
SER A 334
TRP A 303
GLN A 216
 None
 1.42A 1eiiA-5x4tA:
undetectable		 1eiiA-5x4tA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 12 LEU A 308
ALA A 288
SER A 218
LEU A 219
LEU A 247
 None
 1.37A 1ya3B-5x4tA:
undetectable		 1ya3B-5x4tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 6 GLY A  16
GLY A  23
PHE A  46
PHE A  10
 None
None
FMN  A 401 (-3.4A)
None
 0.94A 2qx6A-5x4tA:
undetectable
2qx6B-5x4tA:
undetectable		 2qx6A-5x4tA:
19.43
2qx6B-5x4tA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 12 SER A  15
GLN A  48
ILE A  22
SER A  26
PHE A  46
 None
FMN  A 401 (-2.9A)
FMN  A 401 (-4.2A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.4A)
 1.44A 2vdyB-5x4tA:
undetectable		 2vdyB-5x4tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 12 GLY A 335
THR A 282
SER A 243
SER A 159
ALA A 340
 None
 0.77A 3d91A-5x4tA:
undetectable		 3d91A-5x4tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 4 ILE A   7
PHE A  47
ILE A  45
THR A   5
 None
 1.15A 3ia4A-5x4tA:
undetectable		 3ia4A-5x4tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 11 VAL A 350
ILE A 343
GLY A 344
SER A 236
THR A 162
 None
 1.03A 3kw2B-5x4tA:
undetectable		 3kw2B-5x4tA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 10 ILE A 215
PHE A 291
THR A 330
SER A 334
ILE A 325
 None
 1.19A 3um5A-5x4tA:
undetectable		 3um5A-5x4tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 10 ILE A 215
PHE A 291
THR A 330
SER A 334
ILE A 325
 None
 1.16A 3um5B-5x4tA:
undetectable		 3um5B-5x4tA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 10 ILE A   7
LEU A  39
PHE A  47
ILE A  45
THR A   5
 None
FMN  A 401 ( 4.6A)
None
None
None
 1.25A 4g8zX-5x4tA:
undetectable		 4g8zX-5x4tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		5 / 10 ALA A 340
VAL A 158
SER A 333
SER A 334
GLY A 336
 None
 1.38A 4xp1A-5x4tA:
undetectable		 4xp1A-5x4tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 6 TYR A 323
LEU A 278
GLY A 246
PHE A 291
 None
 1.02A 5nooC-5x4tA:
undetectable		 5nooC-5x4tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		3 / 3 ILE A 108
ASN A 100
CYH A  41
 None
 0.88A 6bp4A-5x4tA:
undetectable		 6bp4A-5x4tA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 6 PHE A 163
LEU A 225
LEU A 241
ARG A 229
 None
 1.00A 6e43A-5x4tA:
undetectable		 6e43A-5x4tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 6 PHE A 163
LEU A 225
LEU A 241
ARG A 229
 None
 1.03A 6e43B-5x4tA:
undetectable		 6e43B-5x4tA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5x4t PHOTOACTIVATED
ADENYLYL CYCLASE
(Cyanobacteria) 		4 / 6 PHE A 163
LEU A 225
LEU A 241
ARG A 229
 None
 1.02A 6e43C-5x4tA:
undetectable		 6e43C-5x4tA:
21.65