SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 7 TYR A 193
VAL A 211
ILE A 224
TYR A 225
GLY A 241
 None
 0.95A 11gsA-5x55A:
undetectable		 11gsA-5x55A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 10 TYR A 193
VAL A 211
ILE A 224
TYR A 225
GLY A 241
 None
 0.98A 13gsA-5x55A:
undetectable		 13gsA-5x55A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.81A 2gssA-5x55A:
undetectable		 2gssA-5x55A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.81A 2gssB-5x55A:
undetectable		 2gssB-5x55A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 5 ILE A 183
PRO A 180
PHE A 137
ILE A 254
 None
 1.14A 2hjhA-5x55A:
undetectable		 2hjhA-5x55A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.80A 3gssA-5x55A:
undetectable		 3gssA-5x55A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.80A 3gssB-5x55A:
undetectable		 3gssB-5x55A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.86A 3hjoA-5x55A:
undetectable		 3hjoA-5x55A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 VAL A 217
TYR A 225
LYS A 239
PRO A 238
 None
 0.96A 3hs4A-5x55A:
undetectable		 3hs4A-5x55A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 TYR A 193
VAL A 211
ILE A 224
GLY A 241
 None
 0.85A 3n9jA-5x55A:
undetectable		 3n9jA-5x55A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 LEU A 279
ILE A 247
VAL A 177
LEU A 178
 None
 0.70A 3r9vA-5x55A:
undetectable
3r9vB-5x55A:
undetectable		 3r9vA-5x55A:
22.19
3r9vB-5x55A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ILE A 254
THR A 276
VAL A 177
PHE A 137
 None
 1.34A 4iarA-5x55A:
undetectable		 4iarA-5x55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 HIS A 350
TRP A 368
SER A 316
 None
 1.03A 4lrhD-5x55A:
undetectable		 4lrhD-5x55A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		8 / 8 GLY A 189
GLN A 190
TYR A 193
SER A 208
PHE A 209
SER A 220
ASN A 255
HIS A 318
 None
 0.85A 4wryA-5x55A:
26.6		 4wryA-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		8 / 8 GLY A 189
GLN A 190
TYR A 193
SER A 208
PHE A 209
SER A 220
ASN A 255
HIS A 318
 None
 0.94A 4wrzA-5x55A:
26.3		 4wrzA-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		6 / 7 GLY A 189
GLN A 190
TYR A 193
SER A 208
PHE A 209
ASN A 255
 None
 0.85A 4ws0A-5x55A:
26.0		 4ws0A-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		6 / 7 GLY A 189
TYR A 193
SER A 208
PHE A 209
ASN A 255
HIS A 318
 None
 0.97A 4ws0A-5x55A:
26.0		 4ws0A-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		6 / 8 GLY A 189
GLN A 190
TYR A 193
SER A 208
PHE A 209
ASN A 255
 None
 0.85A 4ws1A-5x55A:
26.1		 4ws1A-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		7 / 8 GLY A 189
TYR A 193
SER A 208
PHE A 209
SER A 220
ASN A 255
HIS A 318
 None
 0.91A 4ws1A-5x55A:
26.1		 4ws1A-5x55A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.30A 5a06A-5x55A:
undetectable		 5a06A-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.30A 5a06C-5x55A:
undetectable		 5a06C-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.28A 5a06D-5x55A:
undetectable		 5a06D-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.32A 5a06E-5x55A:
undetectable		 5a06E-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ARG A 305
ASP A 281
TYR A 140
TYR A 146
 None
 1.31A 5a06F-5x55A:
undetectable		 5a06F-5x55A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 9 ILE A 247
LEU A 248
THR A  99
ARG A  96
ILE A  98
 None
 1.49A 5ifuB-5x55A:
undetectable		 5ifuB-5x55A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 PHE A 351
VAL A 185
ILE A 224
PRO A 319
VAL A 293
 None
 1.19A 5im2A-5x55A:
undetectable		 5im2A-5x55A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 ASP A 191
TRP A 272
HIS A 268
TYR A 146
 None
 1.46A 5ov9A-5x55A:
1.4		 5ov9A-5x55A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5x55 PROBABLE URACIL-DNA
GLYCOSYLASE
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 LEU A 370
ASN A 355
LEU A 228
 None
 0.54A 6exiD-5x55A:
undetectable		 6exiD-5x55A:
13.51