SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 PHE A1012
THR A 791
VAL A1128
VAL A1022
None
1.19A 1uyuA-5x59A:
undetectable
1uyuA-5x59A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 9 PHE A 116
LEU A 284
PHE A 112
PHE A 183
LEU A 265
None
1.26A 1wrkA-5x59A:
undetectable
1wrkB-5x59A:
undetectable
1wrkA-5x59A:
4.74
1wrkB-5x59A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 ALA A 336
PHE A 323
ILE A  48
ASP A  54
None
1.09A 1yc2D-5x59A:
undetectable
1yc2D-5x59A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 HIS A1122
HIS A1138
VAL A1139
PHE A1001
PHE A1126
None
0.99A 1ydbA-5x59A:
undetectable
1ydbA-5x59A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 TYR A 809
ARG A1074
VAL A 804
TYR A 932
None
1.12A 2fl5E-5x59A:
undetectable
2fl5F-5x59A:
undetectable
2fl5E-5x59A:
11.01
2fl5F-5x59A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 SER A 426
THR A 574
PHE A 446
None
0.69A 2x91A-5x59A:
2.7
2x91A-5x59A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 ILE A 250
LEU A 273
TYR A 144
THR A 178
NAG  A1402 ( 4.5A)
None
None
None
1.05A 3ag2N-5x59A:
undetectable
3ag2W-5x59A:
undetectable
3ag2N-5x59A:
16.77
3ag2W-5x59A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 LEU A1134
GLN A 796
THR A 797
LEU A 894
None
1.21A 3ce6D-5x59A:
undetectable
3ce6D-5x59A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 9 VAL A 853
SER A 950
ILE A 955
ILE A 795
GLY A1133
None
1.17A 3cv9A-5x59A:
undetectable
3cv9A-5x59A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 ALA A  53
ASP A  54
ILE A  48
ILE A 337
ILE A  56
None
0.98A 3ekxB-5x59A:
undetectable
3ekxB-5x59A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 PHE A1001
GLY A 789
PHE A 788
PHE A 977
None
1.05A 3ko0D-5x59A:
undetectable
3ko0E-5x59A:
undetectable
3ko0D-5x59A:
6.21
3ko0E-5x59A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 GLY A1011
PHE A 869
PHE A 972
PHE A1126
None
1.12A 3ko0L-5x59A:
0.7
3ko0N-5x59A:
0.7
3ko0L-5x59A:
6.21
3ko0N-5x59A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 7 PHE A1126
GLY A1011
PHE A 869
PHE A 972
None
1.04A 3ko0R-5x59A:
undetectable
3ko0T-5x59A:
undetectable
3ko0R-5x59A:
6.21
3ko0T-5x59A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 12 TYR A 663
SER A 743
THR A 744
ALA A 671
ASP A 343
None
1.08A 3lcvB-5x59A:
undetectable
3lcvB-5x59A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 GLN A 796
ASN A1029
LEU A1033
ALA A 901
PHE A 895
None
1.41A 3n23C-5x59A:
undetectable
3n23C-5x59A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 THR A 986
GLY A 982
LEU A 980
ILE A1123
None
0.86A 3nbqB-5x59A:
undetectable
3nbqB-5x59A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 THR A 986
GLY A 982
LEU A 980
ILE A1123
None
0.80A 3nbqC-5x59A:
undetectable
3nbqC-5x59A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 GLN A 796
THR A 797
LEU A 894
None
0.65A 3ondA-5x59A:
undetectable
3ondA-5x59A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 GLN A 796
THR A 797
LEU A 894
None
0.66A 3ondB-5x59A:
undetectable
3ondB-5x59A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 GLN A 576
THR A 477
ASN A 475
None
0.91A 3v4tE-5x59A:
undetectable
3v4tE-5x59A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 TYR A 469
ASP A 444
ARG A 401
VAL A 458
ILE A 480
None
1.37A 4dz2A-5x59A:
undetectable
4dz2B-5x59A:
undetectable
4dz2A-5x59A:
6.77
4dz2B-5x59A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 11 TYR A 469
ASP A 444
ARG A 401
VAL A 458
ILE A 480
None
1.39A 4dz2A-5x59A:
undetectable
4dz2B-5x59A:
undetectable
4dz2A-5x59A:
6.77
4dz2B-5x59A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 TYR A1142
GLN A1119
GLY A1120
SER A1114
None
1.27A 4fu8A-5x59A:
undetectable
4fu8A-5x59A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 4 TYR A 231
THR A 202
VAL A 102
ILE A  31
None
1.46A 4jx1F-5x59A:
undetectable
4jx1F-5x59A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 ILE A 464
PRO A 463
TYR A 541
VAL A 530
None
1.35A 4s0vA-5x59A:
undetectable
4s0vA-5x59A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 6 ILE A 250
LEU A 273
TYR A 144
THR A 178
NAG  A1402 ( 4.5A)
None
None
None
1.06A 5b1aN-5x59A:
undetectable
5b1aW-5x59A:
undetectable
5b1aN-5x59A:
16.77
5b1aW-5x59A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
5 / 12 HIS A 670
ILE A 662
VAL A 659
VAL A 363
LEU A 735
None
1.07A 5bykA-5x59A:
undetectable
5bykA-5x59A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 4 VAL A 958
GLY A 959
ARG A 979
VAL A1107
None
1.11A 5d4nA-5x59A:
undetectable
5d4nB-5x59A:
undetectable
5d4nA-5x59A:
6.30
5d4nB-5x59A:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 VAL A 356
HIS A 670
VAL A 661
None
0.72A 5jmnC-5x59A:
undetectable
5jmnC-5x59A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 ARG A 141
GLU A 249
GLY A 121
TRP A 310
None
0.78A 5kf8A-5x59A:
undetectable
5kf8A-5x59A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 4 SER A1034
THR A 899
ASP A 896
ASP A 902
None
1.49A 5vimA-5x59A:
undetectable
5vimA-5x59A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 4 SER A1034
THR A 899
ASP A 896
ASP A 902
None
1.48A 5vimB-5x59A:
undetectable
5vimB-5x59A:
11.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VYH_A_FOLA409_0
(S PROTEIN)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
10 / 10 TRP A  44
PRO A  45
ARG A  46
PRO A  47
HIS A  81
ALA A 123
GLY A 128
THR A 129
ILE A 140
ALA A 312
None
0.42A 5vyhA-5x59A:
53.5
5vyhA-5x59A:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 8 HIS A 298
PHE A 228
PHE A 183
LEU A 187
None
1.11A 5y2tB-5x59A:
undetectable
5y2tB-5x59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 LYS A 698
ASN A 719
SER A 684
None
1.18A 5yw0A-5x59A:
undetectable
5yw0A-5x59A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
4 / 5 ASN A 220
VAL A  21
LEU A 234
SER A 227
None
NAG  A1409 (-3.3A)
None
None
1.31A 6a7pA-5x59A:
4.8
6a7pA-5x59A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)
5x59 S PROTEIN
(Middle
East
respiratory
syndrome-related
coronavirus)
3 / 3 VAL A 934
ALA A 926
GLN A 800
None
0.69A 6gb9A-5x59A:
undetectable
6gb9A-5x59A:
16.41