SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5x5h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 9 GLU A  71
ASN A 180
ALA A  85
LEU A  89
LEU A 228
 MG  A 405 (-3.5A)
None
None
None
None
 1.28A 1hwiA-5x5hA:
undetectable		 1hwiA-5x5hA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 11 ILE A 369
GLY A 335
GLU A 337
HIS A 261
LEU A 375
 None
 1.39A 1i7qA-5x5hA:
2.4		 1i7qA-5x5hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 8 GLY A 304
SER A 307
ILE A 268
ASP A 263
 None
 0.92A 1jg4A-5x5hA:
undetectable		 1jg4A-5x5hA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 GLY A 158
SER A 307
LEU A 333
HIS A 348
LEU A 362
 None
 1.34A 1zgyA-5x5hA:
undetectable		 1zgyA-5x5hA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		3 / 3 THR A 347
THR A 345
PRO A 343
 None
 0.83A 209dC-5x5hA:
undetectable		 209dC-5x5hA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		3 / 3 SER A  14
ASP A 259
CYH A 262
 None
 0.92A 2br4E-5x5hA:
undetectable		 2br4E-5x5hA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 8 SER A 354
TYR A 111
THR A 110
LEU A 146
 None
 1.16A 2v0zO-5x5hA:
undetectable		 2v0zO-5x5hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 LEU A 376
VAL A 379
VAL A 281
VAL A 308
 None
None
GOL  A 402 (-4.0A)
None
 0.91A 2z97A-5x5hA:
undetectable		 2z97A-5x5hA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 11 LEU A 216
ALA A  69
ALA A  68
LEU A 228
GLN A 232
 None
 1.15A 3bszE-5x5hA:
undetectable		 3bszE-5x5hA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 11 ALA A  78
GLY A  56
SER A 240
VAL A 241
ALA A 244
 None
 0.89A 3dcmX-5x5hA:
undetectable		 3dcmX-5x5hA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 HIS A 261
LEU A 375
VAL A 379
LEU A 272
TYR A 205
 None
 1.38A 3dzyD-5x5hA:
undetectable		 3dzyD-5x5hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 TRP A 148
THR A 126
VAL A 127
LEU A  89
THR A  86
 None
 1.18A 3elzC-5x5hA:
undetectable		 3elzC-5x5hA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 10 ILE A 268
PHE A 271
ILE A 365
THR A 324
LEU A 383
 None
 1.42A 3eqmA-5x5hA:
undetectable		 3eqmA-5x5hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 GLY A  82
VAL A 213
SER A  81
THR A 203
 PLP  A 401 (-3.3A)
PLP  A 401 ( 4.9A)
PLP  A 401 (-3.7A)
PLP  A 401 (-3.4A)
 1.11A 3tj7A-5x5hA:
undetectable
3tj7B-5x5hA:
undetectable		 3tj7A-5x5hA:
20.94
3tj7B-5x5hA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 GLY A  82
VAL A 213
SER A  81
THR A 203
 PLP  A 401 (-3.3A)
PLP  A 401 ( 4.9A)
PLP  A 401 (-3.7A)
PLP  A 401 (-3.4A)
 1.10A 3tj7C-5x5hA:
undetectable
3tj7D-5x5hA:
undetectable		 3tj7C-5x5hA:
20.94
3tj7D-5x5hA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 VAL A 213
SER A  81
THR A 203
GLY A  82
 PLP  A 401 ( 4.9A)
PLP  A 401 (-3.7A)
PLP  A 401 (-3.4A)
PLP  A 401 (-3.3A)
 1.09A 3tj7C-5x5hA:
undetectable
3tj7D-5x5hA:
undetectable		 3tj7C-5x5hA:
20.94
3tj7D-5x5hA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		3 / 3 TYR A 125
GLU A 150
TYR A 107
 None
PLP  A 401 ( 3.8A)
PLP  A 401 (-4.0A)
 0.97A 3ug8A-5x5hA:
undetectable		 3ug8A-5x5hA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 8 LEU A 376
VAL A 379
VAL A 281
ILE A 306
 None
None
GOL  A 402 (-4.0A)
None
 0.87A 4l4cB-5x5hA:
undetectable		 4l4cB-5x5hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 ILE A 114
GLY A 103
VAL A 136
HIS A  99
 None
 0.77A 4oltA-5x5hA:
undetectable		 4oltA-5x5hA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 6 ILE A 114
GLY A 103
VAL A 136
HIS A  99
 None
 0.84A 4oltB-5x5hA:
undetectable		 4oltB-5x5hA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 THR A  66
LEU A  70
PRO A 190
ILE A 162
VAL A 256
 None
None
MG  A 405 (-4.0A)
None
None
 1.46A 5dlvB-5x5hA:
undetectable		 5dlvB-5x5hA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 ALA A  68
ILE A 369
GLY A 304
LEU A 187
PHE A  10
 None
 1.22A 5eshA-5x5hA:
undetectable		 5eshA-5x5hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 ALA A  73
ILE A 369
GLY A 304
LEU A 187
PHE A  10
 None
 1.20A 5eshA-5x5hA:
undetectable		 5eshA-5x5hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 ILE A 206
GLY A 207
ASP A 179
GLU A 150
ALA A  78
 None
None
PLP  A 401 (-3.1A)
PLP  A 401 ( 3.8A)
None
 1.20A 5igvA-5x5hA:
undetectable		 5igvA-5x5hA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		4 / 8 TYR A 186
THR A 253
ARG A 260
ILE A 369
 None
 1.12A 5jhdE-5x5hA:
undetectable
5jhdG-5x5hA:
undetectable		 5jhdE-5x5hA:
20.41
5jhdG-5x5hA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 11 ILE A 268
PHE A 271
ILE A 365
THR A 324
LEU A 383
 None
 1.42A 5jkwA-5x5hA:
undetectable		 5jkwA-5x5hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 10 ILE A 268
PHE A 271
ILE A 365
THR A 324
LEU A 383
 None
 1.41A 5jl7A-5x5hA:
undetectable		 5jl7A-5x5hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 12 THR A 110
VAL A 177
ILE A 147
GLU A 150
THR A 130
 None
None
None
PLP  A 401 ( 3.8A)
None
 1.23A 5w8aA-5x5hA:
undetectable		 5w8aA-5x5hA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 5x5h CYSTATHIONINE
BETA-LYASES/CYSTATHI
ONINE
GAMMA-SYNTHASES
(Corynebacterium
glutamicum) 		5 / 11 SER A 184
GLY A 250
GLY A 207
LEU A 246
VAL A 212
 None
 1.28A 6i5zD-5x5hA:
undetectable		 6i5zD-5x5hA:
25.85